RFCL_PYRHO
ID RFCL_PYRHO Reviewed; 468 AA.
AC O57853;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=PH0113;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
CC -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR EMBL; BA000001; BAA29182.1; -; Genomic_DNA.
DR PIR; G71231; G71231.
DR RefSeq; WP_010884229.1; NC_000961.1.
DR AlphaFoldDB; O57853; -.
DR SMR; O57853; -.
DR STRING; 70601.3256499; -.
DR EnsemblBacteria; BAA29182; BAA29182; BAA29182.
DR GeneID; 1444011; -.
DR KEGG; pho:PH0113; -.
DR eggNOG; arCOG00470; Archaea.
DR OMA; GGWTRYG; -.
DR OrthoDB; 24257at2157; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01508; RfcL; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023935; Rep_factor-C_lsu.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding.
FT CHAIN 1..468
FT /note="Replication factor C large subunit"
FT /id="PRO_0000135963"
FT REGION 422..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..443
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ SEQUENCE 468 AA; 53913 MW; B85739AD2760B5AF CRC64;
MPDVPWIEKY RPRKLSEIVN QEQALEKVRA WIESWLHGNP PKKKALLLAG PPGSGKTTTV
YALAHEYNFE VIELNASDER TYNKIARYVQ AAYTMDIMGK RRKIIFLDEA DNIEPSGAPE
IAKLIDKARN PIIMAANHYW EVPKEIRDRA ELVEYKRLNQ RDVISALVRI LKREGITVPK
EILTEIAKRS SGDLRAAIND LQTIVAGGYE DAKYVLAYRD VEKTVFQSLG MVFSSDNAKR
AKLALMNLDM SPDEFLLWVD ENIPHMYLKP EEMARAYEAI SRADIYLGRA QRTGNYSLWK
YAIDMMTAGV AVAGTKKKGF AKFYPPNTLK MLAESKEERS IRDSIIKKIM KEMHMSKLEA
LETMKILRTI FENNLDLAAH FTVFLELTEK EVEFLAGKEK AGTIWGKTLS IRRRIKETEK
IEEKAVEEKV EEEEAEEEEE EERKEEEKPK AEKKKGKQVT LFDFIKKN
