ID   RFCL_PYRIL              Reviewed;         423 AA.
AC   A1RSA3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=Pisl_0657;
OS   Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=384616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 4184 / JCM 9189 / GEO3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.;
RT   "Complete sequence of Pyrobaculum islandicum DSM 4184.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; CP000504; ABL87835.1; -; Genomic_DNA.
DR   RefSeq; WP_011762411.1; NC_008701.1.
DR   AlphaFoldDB; A1RSA3; -.
DR   SMR; A1RSA3; -.
DR   STRING; 384616.Pisl_0657; -.
DR   EnsemblBacteria; ABL87835; ABL87835; Pisl_0657.
DR   GeneID; 4616887; -.
DR   KEGG; pis:Pisl_0657; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   Proteomes; UP000002595; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..423
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000292185"
FT   BINDING         63..70
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   423 AA;  48336 MW;  5572008D143D0735 CRC64;
     MAIPWVEKYR PKTFEEIVNQ EEAKYTLASW ICAKFKAPRE FCTRWAKKKD KEIVEAKAVL
     LAGPPGIGKT TIVHALAREI KYELIELNAS DVRTGERIKQ VVGRGLREAS LFGYEGKLVL
     FDEVDGLHVK EDLGGLETIV EIIEIAKVPV IMTANNPYDP KFRPLRDIAL VINLKRLSED
     DVVEVLRRIC ANEGAKCEEE ALRSIAKSSL GDLRAAINDL QMYLSSGKKI LTVDDIKRVG
     ERNPQLSMFE ILDRVYRARW FDEARAISFN PSFDWEQYFL WALETIPTVY KDLELMAIAY
     DRLSKADMFL GRIKKTQEWE LLPYALELSL GGISQVKNKP RLPPFIKYGF PQRLLLLAKS
     KEARRRREAL VEYLAQNLHV SKSFVKSELI YVLSAIAKKD HSIIDRLSKA LGINALDIKN
     LLL