ID   RFCL_THEKO              Reviewed;         499 AA.
AC   Q5JHP1;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=TK2219;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-6, AND FUNCTION.
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=14646196; DOI=10.1271/bbb.67.2373;
RA   Kitabayashi M., Nishiya Y., Esaka M., Itakura M., Imanaka T.;
RT   "Gene cloning and function analysis of replication factor C from
RT   Thermococcus kodakaraensis KOD1.";
RL   Biosci. Biotechnol. Biochem. 67:2373-2380(2003).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000305|PubMed:14646196}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; AP006878; BAD86408.1; -; Genomic_DNA.
DR   RefSeq; WP_011251169.1; NC_006624.1.
DR   AlphaFoldDB; Q5JHP1; -.
DR   SMR; Q5JHP1; -.
DR   STRING; 69014.TK2219; -.
DR   EnsemblBacteria; BAD86408; BAD86408; TK2219.
DR   GeneID; 3234371; -.
DR   KEGG; tko:TK2219; -.
DR   PATRIC; fig|69014.16.peg.2175; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   InParanoid; Q5JHP1; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   PhylomeDB; Q5JHP1; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Direct protein sequencing; DNA replication;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..499
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135964"
FT   REGION          428..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..469
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..499
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         50..57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   499 AA;  57275 MW;  90D1610E2C0CCBA0 CRC64;
     MTEVPWVEKY RPRKLSEIVN QEKALEQVRA WVEAWLHGNP PKKKALLLAG PPGVGKTTTV
     YALANEYGFE VIELNASDER TYEKIERYVQ AAYTMDILGK RRKLIFLDEA DNIEPSGARE
     IAKLIDKARN PIIMSANHYW EVPREIRNKA QIVEYKRLTQ RDIIKALVRI LKREGLEVPK
     EVLYEIAKRA NGDLRAAVND LQTVVTGGVE DAVEVLAYRD TEKSVFQALA QLFATDNAKR
     AKLAVLGVDM MPNELLQWID ENVPYVYYRP EDIARAYEAL SRADIYLGRA QRTGNYGLWK
     YATDMMTAGV AVAGIKKKGF VKIYPPKTIK LLTESKEERS LRDSVIKKIM SEMHMAKLEA
     IETLRYLRVI FENNPDLAAH FVVFLDLSEK EVEFITGDKE KAKTIWAKSM NIEKKLKKEG
     ELEARAKEAE RRVEAAEEEE TMEAGEPEEE LEEVEEEELT EEELEEAEEE IETVGKKEKP
     EKEKTKKGKQ ATLFDFLKK