ID   RFCL_THEVO              Reviewed;         420 AA.
AC   Q97BC2;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Replication factor C large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE            Short=RFC large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000255|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000255|HAMAP-Rule:MF_01508}; OrderedLocusNames=TV0534;
GN   ORFNames=TVG0524887;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA   Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA   Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT   Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000255|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01508}.
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DR   EMBL; BA000011; BAB59676.1; -; Genomic_DNA.
DR   RefSeq; WP_010916792.1; NC_002689.2.
DR   AlphaFoldDB; Q97BC2; -.
DR   SMR; Q97BC2; -.
DR   STRING; 273116.14324749; -.
DR   EnsemblBacteria; BAB59676; BAB59676; BAB59676.
DR   GeneID; 1441050; -.
DR   KEGG; tvo:TVG0524887; -.
DR   eggNOG; arCOG00470; Archaea.
DR   HOGENOM; CLU_027255_1_1_2; -.
DR   OMA; GGWTRYG; -.
DR   OrthoDB; 24257at2157; -.
DR   PhylomeDB; Q97BC2; -.
DR   Proteomes; UP000001017; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding.
FT   CHAIN           1..420
FT                   /note="Replication factor C large subunit"
FT                   /id="PRO_0000135969"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01508"
SQ   SEQUENCE   420 AA;  48327 MW;  D2F56F90C7CA31F9 CRC64;
     MEWADKYRPK RIEDLIVSEE IRQKIQSWID AWEEGSPKKR ALILYGVQGS GKTSAAYAIA
     GTFGLPVVEM NASEQRNRES MKATALMASL YADLGASDFR KPSKVILIDE ADNIFESNNP
     KRGGDTGGVY ELSKIVKETR NPVIITMNDF YEFRKKNYSS EVINNSESIE FKPYARRLDR
     NYNEFKKNVR NRIKWIINQE GFSLPDDIIN SIIDKNAPDI RSIINDVEAA AVSQSSISQN
     NDRDTVESVY YLVDKAFKKN YDDTLKSIYG SDVDSDYFIN WVEENLPSKT DDISDLNSAY
     EQLSFADHIL WAIERKRHFD LMTFPMEIAG GLAYYIENPK HEYVKFHSPS YINSMSRSKE
     RRHALNAVSL KIGLLLHMSG VESLNYVWFY RLMFKVNAGF RDTVYERLNL TQGEEAVLES