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RFCS_PYRHO
ID   RFCS_PYRHO              Reviewed;         855 AA.
AC   O57852;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Replication factor C small subunit;
DE            Short=RFC small subunit;
DE   AltName: Full=Clamp loader small subunit;
DE   Contains:
DE     RecName: Full=Pho RFC intein;
GN   Name=rfcS; OrderedLocusNames=PH0112;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000250}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000250}.
CC   -!- PTM: This protein undergoes a protein self splicing that involves a
CC       post-translational excision of the intervening region (intein) followed
CC       by peptide ligation. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The intein interrupts the potential ATP-binding site.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcS
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29181.1; -; Genomic_DNA.
DR   PIR; F71231; F71231.
DR   AlphaFoldDB; O57852; -.
DR   SMR; O57852; -.
DR   STRING; 70601.3256498; -.
DR   EnsemblBacteria; BAA29181; BAA29181; BAA29181.
DR   KEGG; pho:PH0112; -.
DR   eggNOG; arCOG00469; Archaea.
DR   eggNOG; arCOG03154; Archaea.
DR   OMA; QFADNTR; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 3.10.28.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR003586; Hint_dom_C.
DR   InterPro; IPR003587; Hint_dom_N.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR030934; Intein_C.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_N.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   InterPro; IPR008824; RuvB-like_N.
DR   Pfam; PF14528; LAGLIDADG_3; 2.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   Pfam; PF05496; RuvB_N; 1.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF51294; SSF51294; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR01443; intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; intein_Nterm; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Autocatalytic cleavage; DNA replication; Nucleotide-binding;
KW   Protein splicing.
FT   CHAIN           1..61
FT                   /note="Replication factor C small subunit, 1st part"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000030379"
FT   CHAIN           62..586
FT                   /note="Pho RFC intein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000030380"
FT   CHAIN           587..855
FT                   /note="Replication factor C small subunit, 2nd part"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000030381"
FT   DOMAIN          185..308
FT                   /note="DOD-type homing endonuclease"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00273"
SQ   SEQUENCE   855 AA;  98422 MW;  FAD533FFD08FCF27 CRC64;
     MHNMEEVREV KVLEKPWVEK YRPQRLDEIV GQEHIVKRLK HYVKTGSMPH LLFAGPPGVG
     KCLTGDTKVI ANGQLFELRE LVEKISGGKF GPTPVKGLKV IGIDEDGKLR EFEVQYVYKD
     KTERLIRIRT RLGRELKVTP YHPLLVNRRN GEIKWVKAEE LKPGDKLAVP RFLPIVTGED
     PLAEWLGYFL GGGYADSKEN LIMFTNEDPL LRQRFMELTE KLFSDARIRE ITHENGTSKV
     YVNSKKALKL VNSLGNAHIP KECWRGIRSF LRAYFDCNGG VKGNAIVLAT ASKEMSQEIA
     YALAGFGIIS RIQEYRVIIS GSDNVKKFLN EIGFINRNKL EKALKLVKKD DPGHDGLEIN
     YELISYVKDR LRLSFFNDKR SWSYREAKEI SWELMKEIYY RLDELEKLKE SLSRGILIDW
     NEVAKRIEEV AEETGIRADE LLEYIEGKRK LSFKDYIKIA KVLGIDVEHT IEAMRVFARK
     YSSYAEIGRR LGTWNSSVKT ILESNAVNVE ILERIRKIEL ELIEEILSDE KLKEGIAYLI
     FLSQNELYWD EITKVEELRG EFIIYDLHVP GYHNFIAGNM PTVVHNTTAA LALSRELFGE
     NWRHNFLELN ASDERGINVI REKVKEFART KPIGGASFKI IFLDEADALT QDAQQALRRT
     MEMFSSNVRF ILSCNYSSKI IEPIQSRCAI FRFRPLRDED IAKRLRYIAE NEGLELTEEG
     LQAILYIAEG DMRRAINILQ AAAALDKKIT DENVFMVASR ARPEDIREMM LLALKGNFLK
     AREKLREILL KQGLSGEDVL IQMHKEVFNL PIDEPTKVYL ADKIGEYNFR LVEGANEMIQ
     LEALLAQFTL VGKKK
 
 
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