位置:首页 > 蛋白库 > RFC_ECOLI
RFC_ECOLI
ID   RFC_ECOLI               Reviewed;         388 AA.
AC   P37748;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=O-antigen polymerase;
GN   Name=rfc; Synonyms=yefF; OrderedLocusNames=b2035, JW2020;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=7517390; DOI=10.1128/jb.176.13.4133-4143.1994;
RA   Yao Z., Valvano M.A.;
RT   "Genetic analysis of the O-specific lipopolysaccharide biosynthesis region
RT   (rfb) of Escherichia coli K-12 W3110: identification of genes that confer
RT   group 6 specificity to Shigella flexneri serotypes Y and 4a.";
RL   J. Bacteriol. 176:4133-4143(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / WG1;
RX   PubMed=7517391; DOI=10.1128/jb.176.13.4144-4156.1994;
RA   Stevenson G., Neal B., Liu D., Hobbs M., Packer N.H., Batley M.,
RA   Redmond J.W., Lindquist L., Reeves P.R.;
RT   "Structure of the O antigen of Escherichia coli K-12 and the sequence of
RT   its rfb gene cluster.";
RL   J. Bacteriol. 176:4144-4156(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: May link the O-antigen tetrasaccharide units into long
CC       chains, giving rise to typical smooth LPS.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:15919996}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U03041; AAC31633.1; -; Genomic_DNA.
DR   EMBL; U09876; AAB88404.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75096.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15877.1; -; Genomic_DNA.
DR   PIR; I69644; I69644.
DR   RefSeq; NP_416539.1; NC_000913.3.
DR   RefSeq; WP_000639866.1; NZ_LN832404.1.
DR   AlphaFoldDB; P37748; -.
DR   BioGRID; 4261358; 168.
DR   STRING; 511145.b2035; -.
DR   TCDB; 9.B.67.2.1; the o-antigen polymerase (oap) family.
DR   jPOST; P37748; -.
DR   PaxDb; P37748; -.
DR   PRIDE; P37748; -.
DR   EnsemblBacteria; AAC75096; AAC75096; b2035.
DR   EnsemblBacteria; BAA15877; BAA15877; BAA15877.
DR   GeneID; 945179; -.
DR   KEGG; ecj:JW2020; -.
DR   KEGG; eco:b2035; -.
DR   PATRIC; fig|1411691.4.peg.216; -.
DR   EchoBASE; EB1925; -.
DR   eggNOG; ENOG502ZGEK; Bacteria.
DR   HOGENOM; CLU_711211_0_0_6; -.
DR   OMA; TWNLEVY; -.
DR   BioCyc; EcoCyc:EG11982-MON; -.
DR   UniPathway; UPA00030; -.
DR   PRO; PR:P37748; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Lipopolysaccharide biosynthesis;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..388
FT                   /note="O-antigen polymerase"
FT                   /id="PRO_0000097298"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   388 AA;  44744 MW;  F6B6A10DBA0199FB CRC64;
     MIYLVISVFL ITAFICLYLK KDIFYPAVCV NIIFALVLLG YEITSDIYAF QLNDATLIFL
     LCNVLTFTLS CLLTESVLDL NIRKVNNAIY SIPSKKVHNV GLLVISFSMI YICMRLSNYQ
     FGTSLLSYMN LIRDADVEDT SRNFSAYMQP IILTTFALFI WSKKFTNTKV SKTFTLLVFI
     VFIFAIILNT GKQIVFMVII SYAFIVGVNR VKHYVYLITA VGVLFSLYML FLRGLPGGMA
     YYLSMYLVSP IIAFQEFYFQ QVSNSASSHV FWFFERLMGL LTGGVSMSLH KEFVWVGLPT
     NVYTAFSDYV YISAELSYLM MVIHGCISGV LWRLSRNYIS VKIFYSYFIY TFSFIFYHES
     FMTNISSWIQ ITLCIIVFSQ FLKAQKIK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024