ID   RFC_SALMU               Reviewed;         399 AA.
AC   Q00474;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=O-antigen polymerase;
GN   Name=rfc;
OS   Salmonella muenchen.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M67;
RX   PubMed=1379320; DOI=10.1111/j.1365-2958.1992.tb00859.x;
RA   Brown P.K., Romana L.K., Reeves P.R.;
RT   "Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen
RT   (strain M67): the genetic basis of the polymorphism between groups C2 and
RT   B.";
RL   Mol. Microbiol. 6:1385-1394(1992).
CC   -!- FUNCTION: May link the O-antigen tetrasaccharide units into long
CC       chains, giving rise to typical smooth LPS.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; X61917; CAA43912.1; -; Genomic_DNA.
DR   RefSeq; WP_000936591.1; NZ_VUJE01000001.1.
DR   AlphaFoldDB; Q00474; -.
DR   PATRIC; fig|596.10.peg.4306; -.
DR   BioCyc; MetaCyc:MON-21436; -.
DR   UniPathway; UPA00030; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR007016; O-antigen_ligase-related.
DR   Pfam; PF04932; Wzy_C; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipopolysaccharide biosynthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..399
FT                   /note="O-antigen polymerase"
FT                   /id="PRO_0000097299"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   399 AA;  44824 MW;  DE4620F0FDC20ECB CRC64;
     MLPFPPGAIL RDVLNVFFVA LVLVRFVIDR KKTYFPLVFT IFSWSAVILW VIALTIFSPD
     KIQAIMGGRS YILFPAVFIA LVILKVSYPQ SLNIEKIVCY IIFLMFMVAT ISIIDVLMNG
     EFIKLLGYDE HYAGEQLNLI NSYDGMVRAT GGFSDALNFG YMLTLGVLLC MECFSQGYKR
     LLMLIISFVL FIAICMSLTR GAILVAALIY ALYIISNRKM LFCGITLFVI IIPVLAISTN
     IFDNYTEILI GRFTDSSQAS RGSTQGRIDM AINSLNFLSE HPSGIGLGTQ GSGNMLSVKD
     NRLNTDNYFF WIALETGIIG LIINIIYLAS QFYSSTLLNR IYGSHCSNMH YRLYFLFGSI
     YFISAALSSA PSSSTFSIYY WTVLALIPFL KLTNRRCTR