ID   RFC_SALTI               Reviewed;         407 AA.
AC   P0A236; P26479;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=O-antigen polymerase;
GN   Name=rfc; OrderedLocusNames=STY1779, t1212;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: May link the O-antigen tetrasaccharide units into long
CC       chains, giving rise to typical smooth LPS. {ECO:0000250}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AL513382; CAD02021.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68867.1; -; Genomic_DNA.
DR   RefSeq; NP_456180.1; NC_003198.1.
DR   RefSeq; WP_000905563.1; NZ_WSUR01000011.1.
DR   AlphaFoldDB; P0A236; -.
DR   STRING; 220341.16502859; -.
DR   TCDB; 9.B.128.3.1; the o-antigen polymerase, wzye (wzye) family.
DR   EnsemblBacteria; AAO68867; AAO68867; t1212.
DR   KEGG; stt:t1212; -.
DR   KEGG; sty:STY1779; -.
DR   PATRIC; fig|220341.7.peg.1791; -.
DR   eggNOG; ENOG50327N8; Bacteria.
DR   HOGENOM; CLU_057683_0_0_6; -.
DR   OMA; AYIFISS; -.
DR   UniPathway; UPA00030; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipopolysaccharide biosynthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..407
FT                   /note="O-antigen polymerase"
FT                   /id="PRO_0000097300"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  47461 MW;  AF187D8633D9CEDE CRC64;
     MLIISYIALC LLFIVYLYTL SVRIEGKIIN VMVPYLIITV PTLYVFEGIF VYLSEVQNYT
     VEYLFFYTCY ITYIASFVIS YLYTQRKPIY NKSNTKNKPR YVFTSLLFTF LAFIIYLPVL
     MEFREYILSP RRIYELTRTG YGIYFYPSLM FSLVASICAF FTYKKSKLFC ISIVLFNCIL
     IFLHGNKGPI FSIFIAFILY LSYIENKKIK FMFLVKSFAV IAVIVTAFFA YTFTDGNPIE
     NMANYSDYTR NAVLVASSNF DFMYGKLLME SEVYSRIPRA IWPDKPEDFG ALYLAKVFFP
     DAFYRNQGAP AFGYGELYAD FGLFTPVWLV ISGVFKGVLA KYFSNKTQET KSAHYFIMFL
     FCIGISVIPV SMGWLFPEHL MIAFMVYIAS SFVFSEHIRF VLLRNNK