RFESD_HUMAN
ID RFESD_HUMAN Reviewed; 157 AA.
AC Q8TAC1; J3KPH1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Rieske domain-containing protein;
GN Name=RFESD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-153 (ISOFORM 2).
RC TISSUE=Fetal pancreas;
RA Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K.,
RA Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L.,
RA Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A.,
RA Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M.,
RA McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.;
RT "Endocrine pancreas consortium.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00628};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|PROSITE-
CC ProRule:PRU00628};
CC -!- INTERACTION:
CC Q8TAC1; P09105: HBQ1; NbExp=9; IntAct=EBI-10271664, EBI-10193656;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAC1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAC1-2; Sequence=VSP_044452;
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DR EMBL; AC008547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471084; EAW96043.1; -; Genomic_DNA.
DR EMBL; CH471084; EAW96045.1; -; Genomic_DNA.
DR EMBL; BC024023; AAH24023.1; -; mRNA.
DR EMBL; BC035110; AAH35110.1; -; mRNA.
DR EMBL; BC048979; AAH48979.1; -; mRNA.
DR EMBL; BM263054; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS4075.1; -. [Q8TAC1-1]
DR CCDS; CCDS47248.1; -. [Q8TAC1-2]
DR RefSeq; NP_001124537.1; NM_001131065.1. [Q8TAC1-2]
DR RefSeq; NP_001124538.1; NM_001131066.1. [Q8TAC1-2]
DR RefSeq; NP_775498.1; NM_173362.3. [Q8TAC1-1]
DR RefSeq; XP_011541662.1; XM_011543360.2. [Q8TAC1-2]
DR RefSeq; XP_011541663.1; XM_011543361.2.
DR RefSeq; XP_016864902.1; XM_017009413.1. [Q8TAC1-2]
DR AlphaFoldDB; Q8TAC1; -.
DR SMR; Q8TAC1; -.
DR BioGRID; 130435; 10.
DR IntAct; Q8TAC1; 1.
DR STRING; 9606.ENSP00000413592; -.
DR iPTMnet; Q8TAC1; -.
DR PhosphoSitePlus; Q8TAC1; -.
DR BioMuta; RFESD; -.
DR DMDM; 74730342; -.
DR EPD; Q8TAC1; -.
DR jPOST; Q8TAC1; -.
DR MassIVE; Q8TAC1; -.
DR MaxQB; Q8TAC1; -.
DR PaxDb; Q8TAC1; -.
DR PeptideAtlas; Q8TAC1; -.
DR PRIDE; Q8TAC1; -.
DR ProteomicsDB; 73854; -. [Q8TAC1-1]
DR Antibodypedia; 4298; 183 antibodies from 18 providers.
DR DNASU; 317671; -.
DR Ensembl; ENST00000311364.8; ENSP00000309229.4; ENSG00000175449.14. [Q8TAC1-1]
DR Ensembl; ENST00000380005.9; ENSP00000369341.4; ENSG00000175449.14. [Q8TAC1-2]
DR Ensembl; ENST00000458310.1; ENSP00000413592.1; ENSG00000175449.14. [Q8TAC1-2]
DR GeneID; 317671; -.
DR KEGG; hsa:317671; -.
DR MANE-Select; ENST00000380005.9; ENSP00000369341.4; NM_001131066.2; NP_001124538.1. [Q8TAC1-2]
DR UCSC; uc003klf.4; human. [Q8TAC1-1]
DR CTD; 317671; -.
DR DisGeNET; 317671; -.
DR GeneCards; RFESD; -.
DR HGNC; HGNC:29587; RFESD.
DR HPA; ENSG00000175449; Tissue enhanced (bone).
DR neXtProt; NX_Q8TAC1; -.
DR OpenTargets; ENSG00000175449; -.
DR PharmGKB; PA162401171; -.
DR VEuPathDB; HostDB:ENSG00000175449; -.
DR eggNOG; ENOG502S06W; Eukaryota.
DR GeneTree; ENSGT00390000018225; -.
DR HOGENOM; CLU_113767_0_0_1; -.
DR InParanoid; Q8TAC1; -.
DR OMA; SAVPKWC; -.
DR PhylomeDB; Q8TAC1; -.
DR TreeFam; TF333320; -.
DR PathwayCommons; Q8TAC1; -.
DR SignaLink; Q8TAC1; -.
DR BioGRID-ORCS; 317671; 5 hits in 1037 CRISPR screens.
DR GenomeRNAi; 317671; -.
DR Pharos; Q8TAC1; Tdark.
DR PRO; PR:Q8TAC1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TAC1; protein.
DR Bgee; ENSG00000175449; Expressed in secondary oocyte and 110 other tissues.
DR ExpressionAtlas; Q8TAC1; baseline and differential.
DR Genevisible; Q8TAC1; HS.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.102.10.10; -; 1.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR Pfam; PF00355; Rieske; 1.
DR SUPFAM; SSF50022; SSF50022; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 1: Evidence at protein level;
KW 2Fe-2S; Acetylation; Alternative splicing; Iron; Iron-sulfur;
KW Metal-binding; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..157
FT /note="Rieske domain-containing protein"
FT /id="PRO_0000313813"
FT DOMAIN 16..94
FT /note="Rieske 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT DOMAIN 17..131
FT /note="Rieske 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT BINDING 57
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT BINDING 59
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT BINDING 80
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT BINDING 83
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1
FT /note="M -> MLKCFRNCLRPSSLSTLPLQYGILFPKLLACLVHLHFGHFSSAVISV
FT TSFYLSM (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_044452"
SQ SEQUENCE 157 AA; 17762 MW; E959948673E776F8 CRC64;
MNLDGSAQDP EKREYSSVCV GREDDIKKSE RMTAVVHDRE VVIFYHKGEY HAMDIRCYHS
GGPLHLGDIE DFDGRPCIVC PWHKYKITLA TGEGLYQSIN PKDPSAKPKW CSKGIKQRIH
TVTVDNGNIY VTLSNEPFKC DSDFYATGDF KVIKSSS
