RFESD_MOUSE
ID RFESD_MOUSE Reviewed; 157 AA.
AC Q8K2P6; Q3TQH9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Rieske domain-containing protein;
GN Name=Rfesd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 2-157, AND IRON-SULFUR BINDING
RP SITES.
RX PubMed=18703841; DOI=10.1107/s0907444908021653;
RA Levin E.J., Elsen N.L., Seder K.D., McCoy J.G., Fox B.G.,
RA Phillips G.N. Jr.;
RT "X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus.";
RL Acta Crystallogr. D 64:933-940(2008).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00628};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|PROSITE-
CC ProRule:PRU00628};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2P6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2P6-2; Sequence=VSP_030156, VSP_030157;
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DR EMBL; AK040255; BAC30553.1; -; mRNA.
DR EMBL; AK163574; BAE37403.1; -; mRNA.
DR EMBL; BC030381; AAH30381.1; -; mRNA.
DR CCDS; CCDS26654.1; -. [Q8K2P6-1]
DR RefSeq; NP_001124540.1; NM_001131068.1. [Q8K2P6-1]
DR RefSeq; NP_001124541.1; NM_001131069.1. [Q8K2P6-1]
DR RefSeq; NP_849247.3; NM_178916.5. [Q8K2P6-1]
DR PDB; 3D89; X-ray; 2.07 A; A=2-157.
DR PDBsum; 3D89; -.
DR AlphaFoldDB; Q8K2P6; -.
DR SMR; Q8K2P6; -.
DR STRING; 10090.ENSMUSP00000055763; -.
DR PhosphoSitePlus; Q8K2P6; -.
DR MaxQB; Q8K2P6; -.
DR PaxDb; Q8K2P6; -.
DR PRIDE; Q8K2P6; -.
DR ProteomicsDB; 255294; -. [Q8K2P6-1]
DR ProteomicsDB; 255295; -. [Q8K2P6-2]
DR Antibodypedia; 4298; 183 antibodies from 18 providers.
DR DNASU; 218341; -.
DR Ensembl; ENSMUST00000050997; ENSMUSP00000055763; ENSMUSG00000043190. [Q8K2P6-1]
DR Ensembl; ENSMUST00000167271; ENSMUSP00000130366; ENSMUSG00000043190. [Q8K2P6-1]
DR Ensembl; ENSMUST00000179078; ENSMUSP00000136314; ENSMUSG00000043190. [Q8K2P6-1]
DR GeneID; 218341; -.
DR KEGG; mmu:218341; -.
DR UCSC; uc007rgd.1; mouse. [Q8K2P6-1]
DR CTD; 317671; -.
DR MGI; MGI:2145198; Rfesd.
DR VEuPathDB; HostDB:ENSMUSG00000043190; -.
DR eggNOG; ENOG502S06W; Eukaryota.
DR GeneTree; ENSGT00390000018225; -.
DR HOGENOM; CLU_113767_2_0_1; -.
DR InParanoid; Q8K2P6; -.
DR OMA; SAVPKWC; -.
DR OrthoDB; 1458334at2759; -.
DR PhylomeDB; Q8K2P6; -.
DR TreeFam; TF333320; -.
DR BioGRID-ORCS; 218341; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Rfesd; mouse.
DR EvolutionaryTrace; Q8K2P6; -.
DR PRO; PR:Q8K2P6; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8K2P6; protein.
DR Bgee; ENSMUSG00000043190; Expressed in spermatocyte and 226 other tissues.
DR Genevisible; Q8K2P6; MM.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008942; F:nitrite reductase [NAD(P)H] activity; IEA:InterPro.
DR Gene3D; 2.102.10.10; -; 1.
DR InterPro; IPR012748; Rieske-like_NirD.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR Pfam; PF13806; Rieske_2; 1.
DR SUPFAM; SSF50022; SSF50022; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 1: Evidence at protein level;
KW 2Fe-2S; 3D-structure; Acetylation; Alternative splicing; Iron; Iron-sulfur;
KW Metal-binding; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..157
FT /note="Rieske domain-containing protein"
FT /id="PRO_0000313814"
FT DOMAIN 16..127
FT /note="Rieske 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT DOMAIN 17..131
FT /note="Rieske 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT BINDING 57
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT BINDING 59
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT BINDING 80
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT BINDING 83
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8TAC1"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TAC1"
FT VAR_SEQ 71..110
FT /note="DFNGQSCIVCPWHKYKITLATGEGLYQSINPKDPSAKPKW -> VCKIKFTL
FT NKFNVSYILSILFYSLFRLIFIIILAYSYLKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030156"
FT VAR_SEQ 111..157
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030157"
FT STRAND 18..22
FT /evidence="ECO:0007829|PDB:3D89"
FT HELIX 23..29
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 30..36
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 39..46
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 49..56
FT /evidence="ECO:0007829|PDB:3D89"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:3D89"
FT HELIX 64..66
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 75..79
FT /evidence="ECO:0007829|PDB:3D89"
FT TURN 81..83
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 86..88
FT /evidence="ECO:0007829|PDB:3D89"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 93..98
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 109..115
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 119..125
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 128..132
FT /evidence="ECO:0007829|PDB:3D89"
FT HELIX 141..145
FT /evidence="ECO:0007829|PDB:3D89"
FT STRAND 147..149
FT /evidence="ECO:0007829|PDB:3D89"
SQ SEQUENCE 157 AA; 17966 MW; F1BD492E5B67A5CE CRC64;
MDPEISEQDE EKKKYTSVCV GREEDIRKSE RMTAVVHDRE VVIFYHKGEY HAMDIRCYHS
GGPLHLGEIE DFNGQSCIVC PWHKYKITLA TGEGLYQSIN PKDPSAKPKW CSKGVKQRIH
TVKVDNGNIY VTLSKEPFKC DSDYYATGEF KVIQSSS
