RFH_ECOLI
ID RFH_ECOLI Reviewed; 166 AA.
AC P28369; P77246;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Putative peptide chain release factor homolog;
DE Short=RF-H;
GN Name=prfH; OrderedLocusNames=b0236, JW0226;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1695895; DOI=10.1128/jb.172.8.4641-4651.1990;
RA Henrich B., Monnerjahn U., Plapp R.;
RT "Peptidase D gene (pepD) of Escherichia coli K-12: nucleotide sequence,
RT transcript mapping, and comparison with other peptidase genes.";
RL J. Bacteriol. 172:4641-4651(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT - 6.0 min (189,987 - 281,416bp) region.";
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP N-TERMINUS.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP IDENTIFICATION OF PROTEIN.
RX PubMed=1408743; DOI=10.1093/nar/20.17.4423;
RA Pel H.J., Rep M., Grivell L.A.;
RT "Sequence comparison of new prokaryotic and mitochondrial members of the
RT polypeptide chain release factor family predicts a five-domain model for
RT release factor structure.";
RL Nucleic Acids Res. 20:4423-4428(1992).
CC -!- FUNCTION: Could be involved in translational termination.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=M34034; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M34034; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR EMBL; U70214; AAB08656.1; -; Genomic_DNA.
DR EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP009048; BAA77905.2; -; Genomic_DNA.
DR PIR; E64748; E64748.
DR AlphaFoldDB; P28369; -.
DR SMR; P28369; -.
DR BioGRID; 4259764; 22.
DR IntAct; P28369; 1.
DR STRING; 316407.85674391; -.
DR PRIDE; P28369; -.
DR EnsemblBacteria; BAA77905; BAA77905; BAA77905.
DR KEGG; ecj:JW0226; -.
DR PATRIC; fig|83333.103.peg.987; -.
DR EchoBASE; EB1459; -.
DR eggNOG; COG1186; Bacteria.
DR HOGENOM; CLU_036856_4_0_6; -.
DR InParanoid; P28369; -.
DR PhylomeDB; P28369; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR017509; Release_fac_PrfH.
DR Pfam; PF00472; RF-1; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR03072; release_prfH; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 5: Uncertain;
KW Protein biosynthesis; Reference proteome.
FT CHAIN 1..166
FT /note="Putative peptide chain release factor homolog"
FT /id="PRO_0000166857"
SQ SEQUENCE 166 AA; 18834 MW; 7555352297B51280 CRC64;
MLETETGRYS DTLRSALVSL DGDNAWALSE SWCGTIQWIC PSPYRPHHGR KNWFLGIGRF
TADEQEQSDA IRYETLRSSG PGGQHVNKTD SAVRATHLAS GISVKVQSER SQHANKRLAR
LLIAWKLEQQ QQENSAALKS QRRMFHHQIE RGNPRRTFTG MAFIEG