RFL1_ARATH
ID RFL1_ARATH Reviewed; 885 AA.
AC Q8L3R3; O04667; O04669; O81401; Q8L3Y7; Q8L4E2; Q8LGP3; Q8LGP4; Q8LGP7;
AC Q8LGP8; Q8LGP9; Q8LGQ0;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Disease resistance protein RFL1;
DE AltName: Full=RPS5-like protein 1;
DE AltName: Full=pNd13/pNd14;
GN Name=RFL1; OrderedLocusNames=At1g12210; ORFNames=T28K15.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9724691; DOI=10.2307/3870609;
RA Warren R.F., Henk A., Mowery P., Holub E., Innes R.W.;
RT "A mutation within the leucine-rich repeat domain of the Arabidopsis
RT disease resistance gene RPS5 partially suppresses multiple bacterial and
RT downy mildew resistance genes.";
RL Plant Cell 10:1439-1452(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC STRAIN=cv. Ang-0, cv. Bla-1, cv. Bur-0, cv. Ct-1, cv. Cvi-0, cv. Kas-0,
RC cv. Landsberg erecta, cv. Mt-0, cv. Pog-0, cv. Tamm-17, cv. Tsu-0, and
RC cv. Wu-0;
RX PubMed=12172007; DOI=10.1073/pnas.172203599;
RA Tian D., Araki H., Stahl E., Bergelson J., Kreitman M.;
RT "Signature of balancing selection in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:11525-11530(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-355.
RC STRAIN=cv. Nd-1;
RA Speulman E., Beynon J.;
RT "Disease resistance gene homologous sequence.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Disease resistance (R) protein.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- MISCELLANEOUS: In contrast to RPS5, which is absent in cv. Landsberg
CC erecta, RFL1 in present in both cv. Columbia and cv. Landsberg erecta.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AF074916; AAC26125.1; -; Genomic_DNA.
DR EMBL; AY062384; AAL65604.1; -; Genomic_DNA.
DR EMBL; AY062385; AAL65606.1; -; Genomic_DNA.
DR EMBL; AY062386; AAL65608.1; -; Genomic_DNA.
DR EMBL; AY062387; AAL65610.1; -; Genomic_DNA.
DR EMBL; AY062390; AAL65614.1; -; Genomic_DNA.
DR EMBL; AY062391; AAL65616.1; -; Genomic_DNA.
DR EMBL; AY062392; AAL65618.1; -; Genomic_DNA.
DR EMBL; AY062394; AAL65621.1; -; Genomic_DNA.
DR EMBL; AY062398; AAL65626.1; -; Genomic_DNA.
DR EMBL; AY062399; AAL65628.1; -; Genomic_DNA.
DR EMBL; AY062403; AAL65633.1; -; Genomic_DNA.
DR EMBL; AY062404; AAL65635.1; -; Genomic_DNA.
DR EMBL; AC022522; AAG12573.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28849.1; -; Genomic_DNA.
DR EMBL; U97224; AAB61689.1; -; Genomic_DNA.
DR EMBL; U97226; AAB61691.1; -; Genomic_DNA.
DR PIR; B86257; B86257.
DR RefSeq; NP_172685.1; NM_101093.2.
DR AlphaFoldDB; Q8L3R3; -.
DR SMR; Q8L3R3; -.
DR STRING; 3702.AT1G12210.1; -.
DR PaxDb; Q8L3R3; -.
DR PRIDE; Q8L3R3; -.
DR ProteomicsDB; 236993; -.
DR EnsemblPlants; AT1G12210.1; AT1G12210.1; AT1G12210.
DR GeneID; 837774; -.
DR Gramene; AT1G12210.1; AT1G12210.1; AT1G12210.
DR KEGG; ath:AT1G12210; -.
DR Araport; AT1G12210; -.
DR TAIR; locus:2201986; AT1G12210.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000427_4_0_1; -.
DR InParanoid; Q8L3R3; -.
DR OMA; LIVYNCE; -.
DR OrthoDB; 236715at2759; -.
DR PhylomeDB; Q8L3R3; -.
DR PRO; PR:Q8L3R3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8L3R3; baseline and differential.
DR Genevisible; Q8L3R3; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; ISS:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..885
FT /note="Disease resistance protein RFL1"
FT /id="PRO_0000212731"
FT DOMAIN 141..443
FT /note="NB-ARC"
FT REPEAT 517..538
FT /note="LRR 1"
FT REPEAT 539..561
FT /note="LRR 2"
FT REPEAT 564..586
FT /note="LRR 3"
FT REPEAT 588..610
FT /note="LRR 4"
FT REPEAT 611..633
FT /note="LRR 5"
FT REPEAT 634..655
FT /note="LRR 6"
FT REPEAT 657..679
FT /note="LRR 7"
FT COILED 27..61
FT /evidence="ECO:0000255"
FT BINDING 183..190
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VARIANT 14
FT /note="E -> V (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 47
FT /note="N -> K (in strain: cv. Ang-0, cv. Bla-1, cv. Bur-0,
FT cv. Ct-1, cv. Cvi-0, cv. Kas-0, cv. Landsberg erecta, cv.
FT Mt-0, cv. Pog-0, cv. Tamm-17, cv. Tsu-0, cv. Wu-0)"
FT VARIANT 57
FT /note="I -> V (in strain: cv. Bur-0)"
FT VARIANT 91
FT /note="S -> I (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 94
FT /note="N -> H (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 112
FT /note="M -> R (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 135
FT /note="V -> E (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 138
FT /note="I -> V (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 143
FT /note="A -> T (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 165
FT /note="D -> N (in strain: cv. Bur-0)"
FT VARIANT 226
FT /note="K -> R (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 275
FT /note="V -> A (in strain: cv. Bur-0)"
FT VARIANT 280..283
FT /note="YPSG -> FPNR (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 281
FT /note="P -> S (in strain: cv. Ang-0 and cv. Tsu-0)"
FT VARIANT 289
FT /note="V -> I (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 294
FT /note="H -> R (in strain: cv. Ang-0, cv. Bla-1, cv. Bur-0,
FT cv. Ct-1, cv. Cvi-0, cv. Kas-0, cv. Landsberg erecta, cv.
FT Mt-0, cv. Pog-0, cv. Tamm-17, cv. Tsu-0, cv. Wu-0)"
FT VARIANT 306
FT /note="N -> D (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 310
FT /note="I -> V (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 342
FT /note="R -> C (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 349
FT /note="C -> R (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 380
FT /note="S -> SS (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 394
FT /note="I -> L (in strain: cv. Wu-0)"
FT VARIANT 407
FT /note="A -> V (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 419
FT /note="E -> D (in strain: cv. Ct-1 and cv. Tamm-17)"
FT VARIANT 435
FT /note="E -> K (in strain: cv. Bur-0)"
FT VARIANT 468
FT /note="A -> T (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 473
FT /note="V -> F (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 479
FT /note="M -> V (in strain: cv. Ang-0,, cv. Bla-1, cv. Bur-0,
FT cv. Ct-1, cv. Cvi-0, cv. Kas-0, cv. Landsberg erecta, cv.
FT Mt-0, cv. Pog-0, cv. Tamm-17, cv. Tsu-0, cv. Wu-0)"
FT VARIANT 488
FT /note="F -> S (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 511
FT /note="E -> K (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 527
FT /note="N -> D (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 532
FT /note="L -> F (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 607
FT /note="H -> Q (in strain: cv. Bla-1, cv. Bur-0, cv. Cvi,
FT cv. Kas-0, cv. Landsberg erecta, cv. Mt-0 and cv. Wu-0)"
FT VARIANT 640
FT /note="L -> R (in strain: cv. Wu-0)"
FT VARIANT 702
FT /note="V -> I (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 711
FT /note="H -> T (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 724
FT /note="W -> C (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 730
FT /note="K -> KK (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 734
FT /note="K -> N (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 739
FT /note="N -> S (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 782
FT /note="I -> L (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 789
FT /note="A -> V (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 800
FT /note="Q -> A (in strain: cv. Cvi-0, cv. Kas-0, cv.
FT Landsberg erecta and cv. Mt-0)"
FT VARIANT 846
FT /note="K -> T (in strain: cv. Bla-1 and cv. Bur-0)"
FT VARIANT 847..855
FT /note="SVVKVEEFV -> VLSKLKNLS (in strain: cv. Cvi-0 and cv.
FT Mt-0)"
FT VARIANT 875..876
FT /note="QY -> RH (in strain: cv. Kas-0 and cv. Landsberg
FT erecta)"
FT VARIANT 877
FT /note="R -> G (in strain: cv. Landsberg erecta)"
FT VARIANT 881
FT /note="T -> S (in strain: cv. Kas-0 and cv. Landsberg
FT erecta)"
FT CONFLICT 242
FT /note="K -> E (in Ref. 5; AAB61689)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="R -> K (in Ref. 5; AAB61689)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="K -> I (in Ref. 5; AAB61689)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="H -> P (in Ref. 5; AAB61691)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="K -> E (in Ref. 5; AAB61689)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 885 AA; 101445 MW; 4E5F1A0CAB828914 CRC64;
MGGCVSVSLS CDREVNQFSQ WLCVSGSYIQ NLSENLASLQ KAMGVLNAKR DDVQGRINRE
EFTGHRRRLA QVQVWLTRIQ TIENQFNDLL STCNAEIQRL CLCGFCSKNV KMSYLYGKRV
IVLLREVEGL SSQGVFDIVT EAAPIAEVEE LPIQSTIVGQ DSMLDKVWNC LMEDKVWIVG
LYGMGGVGKT TLLTQINNKF SKLGGGFDVV IWVVVSKNAT VHKIQKSIGE KLGLVGKNWD
EKNKNQRALD IHNVLRRKKF VLLLDDIWEK VELKVIGVPY PSGENGCKVA FTTHSKEVCG
RMGVDNPMEI SCLDTGNAWD LLKKKVGENT LGSHPDIPQL ARKVSEKCCG LPLALNVIGE
TMSFKRTIQE WRHATEVLTS ATDFSGMEDE ILPILKYSYD SLNGEDAKSC FLYCSLFPED
FEIRKEMLIE YWICEGFIKE KQGREKAFNQ GYDILGTLVR SSLLLEGAKD KDVVSMHDMV
REMALWIFSD LGKHKERCIV QAGIGLDELP EVENWRAVKR MSLMNNNFEK ILGSPECVEL
ITLFLQNNYK LVDISMEFFR CMPSLAVLDL SENHSLSELP EEISELVSLQ YLDLSGTYIE
RLPHGLHELR KLVHLKLERT RRLESISGIS YLSSLRTLRL RDSKTTLDTG LMKELQLLEH
LELITTDISS GLVGELFCYP RVGRCIQHIY IRDHWERPEE SVGVLVLPAI HNLCYISIWN
CWMWEIMIEK TPWKKNLTNP NFSNLSNVRI EGCDGLKDLT WLLFAPNLIN LRVWGCKHLE
DIISKEKAAS VLEKEILPFQ KLECLNLYQL SELKSIYWNA LPFQRLRCLD ILNNCPKLRK
LPLDSKSVVK VEEFVIKYKE KKWIERVEWE DEATQYRFLP TCRLR