ID   RFLB_RAT                Reviewed;         216 AA.
AC   Q6AXS9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Refilin-B;
DE   AltName: Full=Regulator of filamin protein B;
DE            Short=RefilinB;
GN   Name=Rflnb {ECO:0000312|RGD:1359691}; Synonyms=Fam101b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the regulation of the perinuclear actin network
CC       and nuclear shape through interaction with filamins. Plays an essential
CC       role in the formation of cartilaginous skeletal elements.
CC       {ECO:0000250|UniProtKB:Q5SVD0}.
CC   -!- SUBUNIT: Interacts with FLNA and FLNB. {ECO:0000250|UniProtKB:Q5SVD0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q5SVD0}. Note=Colocalizes with FLNA along actin
CC       bundle-like structures. {ECO:0000250|UniProtKB:Q5SVD0}.
CC   -!- SIMILARITY: Belongs to the Refilin family. {ECO:0000305}.
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DR   EMBL; BC079330; AAH79330.1; -; mRNA.
DR   RefSeq; NP_001007612.1; NM_001007611.1.
DR   AlphaFoldDB; Q6AXS9; -.
DR   STRING; 10116.ENSRNOP00000008982; -.
DR   PaxDb; Q6AXS9; -.
DR   PRIDE; Q6AXS9; -.
DR   Ensembl; ENSRNOT00000008982; ENSRNOP00000008982; ENSRNOG00000006674.
DR   GeneID; 287534; -.
DR   KEGG; rno:287534; -.
DR   CTD; 359845; -.
DR   RGD; 1359691; Rflnb.
DR   eggNOG; ENOG502RXSW; Eukaryota.
DR   GeneTree; ENSGT00390000016836; -.
DR   HOGENOM; CLU_107206_0_0_1; -.
DR   InParanoid; Q6AXS9; -.
DR   OMA; YPKKTSA; -.
DR   OrthoDB; 1235968at2759; -.
DR   PhylomeDB; Q6AXS9; -.
DR   TreeFam; TF332387; -.
DR   PRO; PR:Q6AXS9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000006674; Expressed in stomach and 17 other tissues.
DR   Genevisible; Q6AXS9; RN.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:RGD.
DR   GO; GO:0032432; C:actin filament bundle; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031005; F:filamin binding; ISO:RGD.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD.
DR   GO; GO:0061572; P:actin filament bundle organization; ISO:RGD.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; ISO:RGD.
DR   GO; GO:1900158; P:negative regulation of bone mineralization involved in bone maturation; ISO:RGD.
DR   GO; GO:0061182; P:negative regulation of chondrocyte development; ISO:RGD.
DR   GO; GO:0048705; P:skeletal system morphogenesis; ISO:RGD.
DR   InterPro; IPR028215; Refilin.
DR   PANTHER; PTHR31848; PTHR31848; 1.
DR   Pfam; PF15068; FAM101; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..216
FT                   /note="Refilin-B"
FT                   /id="PRO_0000264633"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5W9"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SVD0"
SQ   SEQUENCE   216 AA;  23454 MW;  9EABCDD31776311B CRC64;
     MVGRLSLQDV PELVDTKKKG DGVLDSPDSG LPPSPSPSHW GLAAATGGGG ERAPVAGTLE
     PDATVTSVVP NPASLSHSLA GICSPRLCPL SFGEGVEFDP LPPKEIKYTS SVKYDSERHF
     IDDVQMPLGL VVASCSQTVT CIPNCTWRNY KAEVRFEPRH KPARFLSTTI IYPKYPKTVY
     TTTLDYNCHK KLRRFLSSVE LEATEFLGSD GLLDEC