ID   RFNT_BRUA4              Reviewed;         398 AA.
AC   A6X7E7;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Riboflavin transporter RfnT {ECO:0000305};
GN   Name=rfnT {ECO:0000303|PubMed:25938806};
GN   OrderedLocusNames=Oant_4451 {ECO:0000312|EMBL:ABS17151.1};
OS   Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS   LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=21685287; DOI=10.1128/jb.05335-11;
RA   Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA   Ugalde R.A., Garcia E., Tolmasky M.E.;
RT   "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT   pathogen and symbiont of several eukaryotic hosts.";
RL   J. Bacteriol. 193:4274-4275(2011).
RN   [2]
RP   FUNCTION AS A TRANSPORTER.
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=25938806; DOI=10.1371/journal.pone.0126124;
RA   Gutierrez-Preciado A., Torres A.G., Merino E., Bonomi H.R., Goldbaum F.A.,
RA   Garcia-Angulo V.A.;
RT   "Extensive identification of bacterial riboflavin transporters and their
RT   distribution across bacterial species.";
RL   PLoS ONE 10:E0126124-E0126124(2015).
CC   -!- FUNCTION: Transports riboflavin into the cell.
CC       {ECO:0000269|PubMed:25938806}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000759; ABS17151.1; -; Genomic_DNA.
DR   RefSeq; WP_010660541.1; NC_009668.1.
DR   AlphaFoldDB; A6X7E7; -.
DR   SMR; A6X7E7; -.
DR   STRING; 439375.Oant_4451; -.
DR   TCDB; 2.A.1.81.5; the major facilitator superfamily (mfs).
DR   EnsemblBacteria; ABS17151; ABS17151; Oant_4451.
DR   GeneID; 61314300; -.
DR   KEGG; oan:Oant_4451; -.
DR   PATRIC; fig|439375.7.peg.4627; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_047644_2_0_5; -.
DR   OMA; WNFGLVS; -.
DR   OrthoDB; 1121832at2; -.
DR   Proteomes; UP000002301; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..398
FT                   /note="Riboflavin transporter RfnT"
FT                   /id="PRO_0000438274"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   398 AA;  41659 MW;  EB059513DABF0ADB CRC64;
     MTDATAARRN IVILTIAQAL GASSPPIVIS LGGLVGQKLS SDPALVTLPV SLFNLGLALG
     TLPAAFFMRQ FGRRNAYMLG ALVGAAAGVI AAAGIFAASF LIFCLGTLTA GFYASYVQSY
     RFAATDAATG DMKARAISWV MVGGLVAAIV GPQLVIWTRD TIPDAMFAGS FLSQAVLGLL
     ALPVLFMLRA PKVRKDPNAI HDTGRPLGEI LRSPRFILSV AAGVCSYALM TFVMTAAPIA
     MVGHGHSVDH AALGIQWHVL AMFAPSFFTG KLITRFGKEK ITALGLVLIA FSAIIALGGF
     DVGHFWGALI FLGIGWNFGF IGATAMVTDC HTPAERGKAQ GANDFIMFGT VACASFFAGS
     LLHSSGWETI NWLVFPIVAL VLVPLILRLK PKGAAAEA