ID   RFOX1_BOVIN             Reviewed;         355 AA.
AC   Q17QD3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=RNA binding protein fox-1 homolog 1;
DE   AltName: Full=Ataxin-2-binding protein 1;
DE   AltName: Full=Fox-1 homolog A;
GN   Name=RBFOX1; Synonyms=A2BP1, FOX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC       events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2
CC       to the 3'-splice site. Regulates alternative splicing of tissue-
CC       specific exons and of differentially spliced exons during
CC       erythropoiesis (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the C-terminus of ATXN2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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DR   EMBL; BC118423; AAI18424.1; -; mRNA.
DR   RefSeq; NP_001069286.1; NM_001075818.2.
DR   AlphaFoldDB; Q17QD3; -.
DR   SMR; Q17QD3; -.
DR   STRING; 9913.ENSBTAP00000009490; -.
DR   PaxDb; Q17QD3; -.
DR   GeneID; 521304; -.
DR   KEGG; bta:521304; -.
DR   CTD; 54715; -.
DR   eggNOG; KOG0125; Eukaryota.
DR   InParanoid; Q17QD3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR025670; Fox-1_C_dom.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR017325; RNA-bd_Fox-1.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12414; Fox-1_C; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..355
FT                   /note="RNA binding protein fox-1 homolog 1"
FT                   /id="PRO_0000317109"
FT   DOMAIN          116..174
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            117
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            125
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            126
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            141
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            165
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            175
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         298
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJ43"
SQ   SEQUENCE   355 AA;  38175 MW;  6ACD69164B762E0C CRC64;
     MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP EYTGQTTVPE
     HTLNLYPPAQ SHSEQSAADT SAHTVSGTAT TDDSAPTDGQ PQTQPSENTE NKSQPKRLHV
     SNIPFRFRDP DLRQMFGGFG FVTFENSADA DRAREKLHGT VVEGRKIEVN NATARVMTNK
     KTVNPYTNGW KLNPVVGAVY SPEFYAGTVL LCQANQEGSS MYSAPSSLVY TSAMPGFPYP
     AATAAAAYRG AHLRGRGRTV YNTFRAAAPP PPIPAYGGVV YQDGFYGADI YGGYAAYRYA
     QPTPATAAAY SDRNQFVFVA ADEISCNTSA VTDEFMLPTP TTTHLLQPPP TALVP