ID   RFOX1_DANRE             Reviewed;         373 AA.
AC   Q642J5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=RNA binding protein fox-1 homolog 1;
DE   AltName: Full=Ataxin-2-binding protein 1;
DE   AltName: Full=Fox-1 homolog A;
GN   Name=rbfox1; Synonyms=a2bp1, fox1; ORFNames=zgc:103635;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC       events by binding to 5'-UGCAUGU-3' elements. Regulates alternative
CC       splicing of tissue-specific exons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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DR   EMBL; BC081500; AAH81500.1; -; mRNA.
DR   RefSeq; NP_001005596.1; NM_001005596.1.
DR   AlphaFoldDB; Q642J5; -.
DR   SMR; Q642J5; -.
DR   STRING; 7955.ENSDARP00000107099; -.
DR   PaxDb; Q642J5; -.
DR   Ensembl; ENSDART00000122037; ENSDARP00000107099; ENSDARG00000014746.
DR   GeneID; 449554; -.
DR   KEGG; dre:449554; -.
DR   CTD; 54715; -.
DR   ZFIN; ZDB-GENE-040927-11; rbfox1.
DR   eggNOG; KOG0125; Eukaryota.
DR   GeneTree; ENSGT00940000160685; -.
DR   HOGENOM; CLU_048440_0_0_1; -.
DR   InParanoid; Q642J5; -.
DR   OMA; DXNAFAP; -.
DR   OrthoDB; 871288at2759; -.
DR   PhylomeDB; Q642J5; -.
DR   TreeFam; TF315942; -.
DR   Reactome; R-DRE-6803529; FGFR2 alternative splicing.
DR   PRO; PR:Q642J5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000014746; Expressed in brain and 23 other tissues.
DR   ExpressionAtlas; Q642J5; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0060047; P:heart contraction; IMP:ZFIN.
DR   GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:ZFIN.
DR   GO; GO:0043484; P:regulation of RNA splicing; IMP:ZFIN.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd12407; RRM_FOX1_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR025670; Fox-1_C_dom.
DR   InterPro; IPR034237; FOX1_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR017325; RNA-bd_Fox-1.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12414; Fox-1_C; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..373
FT                   /note="RNA binding protein fox-1 homolog 1"
FT                   /id="PRO_0000317112"
FT   DOMAIN          119..195
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            120
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            128
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            129
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            153
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            158
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            162
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            186
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
FT   SITE            196
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   373 AA;  40309 MW;  8D983B6A573360C4 CRC64;
     MEEKGSKMVE QGNQDAPAPP ETMAQPFPSA QFAPPQNGIP AEYTPSHPHP TPDYSGQTPV
     AEHTLNLYTP AQTHSEPSGP DNSIQAVSGT ATQTDDSAQT DSQQQTQSSE ITEIKTQPKR
     LHVSNIPFRF RDPDLRQMFG QFGKILDVEI IFNERGSKGF GFVTFESSAD ADRAREKLHG
     TVVEGRKIEV NNATARVMTN KKTVNPYANG WKLNPVVGAV YSPEFYAVPG FPYPAATAAA
     AAYRGAHLRG RGRTVYNTFR AAAPPPHIPA YGGVVYQDGF YGADIYGGYT AYRYTQPATA
     TAAAYSDSYG RVYAADPYNH ALAPAATYSV GAMNAFAPLT DAKTRSHADD VGLVLSSLQA
     SIYRGGYSRF APY