RFPLA_HUMAN
ID RFPLA_HUMAN Reviewed; 287 AA.
AC A6NLU0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Ret finger protein-like 4A;
DE AltName: Full=RING finger protein 210;
GN Name=RFPL4A; Synonyms=RFPL4, RNF210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.
RX PubMed=16364311; DOI=10.1016/j.febslet.2005.11.076;
RA Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S., Tschopp J.,
RA Gruetter M.G.;
RT "Structure of the PRYSPRY-domain: implications for autoinflammatory
RT diseases.";
RL FEBS Lett. 580:99-106(2006).
CC -!- SUBUNIT: Interacts with PSMB1, UBE2A and CCNB1.
CC {ECO:0000250|UniProtKB:Q8VH31}.
CC -!- INTERACTION:
CC A6NLU0; Q8N5I3: KCNRG; NbExp=3; IntAct=EBI-21545735, EBI-745755;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VH31}. Nucleus
CC {ECO:0000250|UniProtKB:Q8VH31}.
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DR EMBL; AC008749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46201.1; -.
DR RefSeq; NP_001138486.1; NM_001145014.1.
DR PDB; 2FBE; X-ray; 2.52 A; A/B/C/D=94-287.
DR PDBsum; 2FBE; -.
DR AlphaFoldDB; A6NLU0; -.
DR SMR; A6NLU0; -.
DR BioGRID; 131211; 4.
DR IntAct; A6NLU0; 3.
DR STRING; 9606.ENSP00000392936; -.
DR iPTMnet; A6NLU0; -.
DR PhosphoSitePlus; A6NLU0; -.
DR BioMuta; RFPL4A; -.
DR MassIVE; A6NLU0; -.
DR MaxQB; A6NLU0; -.
DR PaxDb; A6NLU0; -.
DR PeptideAtlas; A6NLU0; -.
DR PRIDE; A6NLU0; -.
DR ProteomicsDB; 1492; -.
DR Antibodypedia; 52665; 87 antibodies from 18 providers.
DR DNASU; 342931; -.
DR Ensembl; ENST00000434937.3; ENSP00000392936.2; ENSG00000223638.4.
DR GeneID; 342931; -.
DR KEGG; hsa:342931; -.
DR MANE-Select; ENST00000434937.3; ENSP00000392936.2; NM_001145014.2; NP_001138486.1.
DR UCSC; uc010yge.3; human.
DR CTD; 342931; -.
DR DisGeNET; 342931; -.
DR GeneCards; RFPL4A; -.
DR HGNC; HGNC:16449; RFPL4A.
DR HPA; ENSG00000223638; Tissue enhanced (epididymis, liver, testis).
DR MIM; 612601; gene.
DR neXtProt; NX_A6NLU0; -.
DR OpenTargets; ENSG00000223638; -.
DR PharmGKB; PA162401186; -.
DR VEuPathDB; HostDB:ENSG00000223638; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163220; -.
DR HOGENOM; CLU_013137_7_1_1; -.
DR InParanoid; A6NLU0; -.
DR OMA; WVGPQLH; -.
DR OrthoDB; 1139938at2759; -.
DR PhylomeDB; A6NLU0; -.
DR TreeFam; TF317532; -.
DR PathwayCommons; A6NLU0; -.
DR SignaLink; A6NLU0; -.
DR BioGRID-ORCS; 342931; 60 hits in 1030 CRISPR screens.
DR EvolutionaryTrace; A6NLU0; -.
DR GenomeRNAi; 342931; -.
DR Pharos; A6NLU0; Tdark.
DR PRO; PR:A6NLU0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NLU0; protein.
DR Bgee; ENSG00000223638; Expressed in right lobe of liver and 37 other tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd15821; SPRY_PRY_RFPL; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR022723; RDM_domain_RFPL.
DR InterPro; IPR038908; RFPL.
DR InterPro; IPR037960; SPRY/PRY_RFPL.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR25462:SF245; PTHR25462:SF245; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF11002; RDM; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..287
FT /note="Ret finger protein-like 4A"
FT /id="PRO_0000300811"
FT DOMAIN 78..276
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 11..53
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT TURN 102..104
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 109..111
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 115..120
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 139..143
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 146..156
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 161..169
FT /evidence="ECO:0007829|PDB:2FBE"
FT TURN 182..185
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 186..192
FT /evidence="ECO:0007829|PDB:2FBE"
FT TURN 193..195
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 196..199
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 201..203
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 205..207
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 215..221
FT /evidence="ECO:0007829|PDB:2FBE"
FT TURN 222..225
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 226..231
FT /evidence="ECO:0007829|PDB:2FBE"
FT TURN 232..234
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 237..241
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 250..257
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 259..262
FT /evidence="ECO:0007829|PDB:2FBE"
FT STRAND 267..269
FT /evidence="ECO:0007829|PDB:2FBE"
FT HELIX 275..278
FT /evidence="ECO:0007829|PDB:2FBE"
SQ SEQUENCE 287 AA; 32238 MW; 53B423A78E3F3E41 CRC64;
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL
SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT
FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
