ID   RFPLA_RAT               Reviewed;         285 AA.
AC   D4ABM4;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Ret finger protein-like 4A;
GN   Name=Rfpl4a; Synonyms=Rfpl4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with PSMB1, UBE2A and CCNB1.
CC       {ECO:0000250|UniProtKB:Q8VH31}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VH31}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8VH31}.
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DR   EMBL; CH474075; EDL75888.1; -; Genomic_DNA.
DR   EMBL; CH474075; EDL75889.1; -; Genomic_DNA.
DR   RefSeq; NP_001099692.1; NM_001106222.1.
DR   AlphaFoldDB; D4ABM4; -.
DR   SMR; D4ABM4; -.
DR   STRING; 10116.ENSRNOP00000021077; -.
DR   PaxDb; D4ABM4; -.
DR   Ensembl; ENSRNOT00000021077; ENSRNOP00000021077; ENSRNOG00000015743.
DR   GeneID; 292583; -.
DR   KEGG; rno:292583; -.
DR   UCSC; RGD:1307409; rat.
DR   CTD; 342931; -.
DR   RGD; 1307409; Rfpl4a.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000163187; -.
DR   HOGENOM; CLU_013137_7_1_1; -.
DR   InParanoid; D4ABM4; -.
DR   OMA; RPFFSHK; -.
DR   OrthoDB; 1139938at2759; -.
DR   PhylomeDB; D4ABM4; -.
DR   TreeFam; TF317532; -.
DR   PRO; PR:D4ABM4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Proteomes; UP000234681; Chromosome 1.
DR   Bgee; ENSRNOG00000015743; Expressed in ovary.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd15821; SPRY_PRY_RFPL; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR022723; RDM_domain_RFPL.
DR   InterPro; IPR037960; SPRY/PRY_RFPL.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF11002; RDM; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..285
FT                   /note="Ret finger protein-like 4A"
FT                   /id="PRO_0000394968"
FT   DOMAIN          78..276
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   ZN_FING         11..53
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   285 AA;  32483 MW;  29A4CB66BA459B14 CRC64;
     MAHFFKENSS CYFCFRYLEN PVYLNCGYIC CFQCLDSLEK SPEGDGVLCP NCSVVSLKED
     IRHAKQLRNL VTTVKDLEPQ LNFILTMDPS MKIFQVNMIL DVDTAQNNLI ISEDLRSVYH
     TSQTQDRKKC AERFDPSPCV LGSSRFTSGC HYWEVVVGTS KEWDIGICKE SINRQEVVYL
     SEKKGFWTVG VRNEEVYAAS TDPLTVLLVN PRLHRVGIFL DLLEKSVSFW DLGDGSHIYT
     FLEIPDTEPF RPFFSPANTY PDEEQVISIC PVMNPSIFGL PVNPV