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RFPLB_HUMAN
ID   RFPLB_HUMAN             Reviewed;         263 AA.
AC   Q6ZWI9; A2RU91;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Ret finger protein-like 4B;
DE   AltName: Full=RING finger protein 211;
GN   Name=RFPL4B; Synonyms=RNF211;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK122906; BAC85513.1; -; mRNA.
DR   EMBL; BC132796; AAI32797.1; -; mRNA.
DR   EMBL; BC132798; AAI32799.1; -; mRNA.
DR   CCDS; CCDS34515.1; -.
DR   RefSeq; NP_001013756.2; NM_001013734.2.
DR   RefSeq; XP_016866386.1; XM_017010897.1.
DR   RefSeq; XP_016866387.1; XM_017010898.1.
DR   AlphaFoldDB; Q6ZWI9; -.
DR   SMR; Q6ZWI9; -.
DR   BioGRID; 138138; 48.
DR   IntAct; Q6ZWI9; 34.
DR   STRING; 9606.ENSP00000423391; -.
DR   iPTMnet; Q6ZWI9; -.
DR   PhosphoSitePlus; Q6ZWI9; -.
DR   BioMuta; RFPL4B; -.
DR   DMDM; 212287933; -.
DR   MassIVE; Q6ZWI9; -.
DR   PaxDb; Q6ZWI9; -.
DR   PRIDE; Q6ZWI9; -.
DR   Antibodypedia; 55115; 132 antibodies from 22 providers.
DR   DNASU; 442247; -.
DR   Ensembl; ENST00000441065.3; ENSP00000423391.1; ENSG00000251258.2.
DR   GeneID; 442247; -.
DR   KEGG; hsa:442247; -.
DR   MANE-Select; ENST00000441065.3; ENSP00000423391.1; NM_001013734.3; NP_001013756.2.
DR   UCSC; uc003pvx.1; human.
DR   CTD; 442247; -.
DR   GeneCards; RFPL4B; -.
DR   HGNC; HGNC:33264; RFPL4B.
DR   HPA; ENSG00000251258; Tissue enriched (testis).
DR   neXtProt; NX_Q6ZWI9; -.
DR   OpenTargets; ENSG00000251258; -.
DR   PharmGKB; PA162401195; -.
DR   VEuPathDB; HostDB:ENSG00000251258; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000163194; -.
DR   HOGENOM; CLU_013137_7_1_1; -.
DR   InParanoid; Q6ZWI9; -.
DR   OMA; MEDPQRF; -.
DR   OrthoDB; 1139938at2759; -.
DR   PhylomeDB; Q6ZWI9; -.
DR   TreeFam; TF317532; -.
DR   PathwayCommons; Q6ZWI9; -.
DR   SignaLink; Q6ZWI9; -.
DR   BioGRID-ORCS; 442247; 11 hits in 1112 CRISPR screens.
DR   GenomeRNAi; 442247; -.
DR   Pharos; Q6ZWI9; Tdark.
DR   PRO; PR:Q6ZWI9; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q6ZWI9; protein.
DR   Bgee; ENSG00000251258; Expressed in placenta and 15 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..263
FT                   /note="Ret finger protein-like 4B"
FT                   /id="PRO_0000274600"
FT   DOMAIN          76..263
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   ZN_FING         11..53
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   VARIANT         234
FT                   /note="G -> D (in dbSNP:rs11153361)"
FT                   /id="VAR_044525"
FT   CONFLICT        177
FT                   /note="E -> G (in Ref. 1; BAC85513)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   263 AA;  29922 MW;  86B45A0564CA3DBB CRC64;
     MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP LCRDVVKVPA
     LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD AATASSLLVF SNDLRSAQCK
     KIHHDLTKDP RLACVLGTPC FSSGQHYWEV EVGEVKSWSL GVCKEPADRK SNDLFPEHGF
     WISMKAGAIH ANTHLERIPA SPRLRRVGIF LDADLEEIQF FDVDNNVLIY THDGFFSLEL
     LCPFFCLELL GEGESGNVLT ICP
 
 
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