ID   RFRNP_HALMA             Reviewed;         224 AA.
AC   Q5V059;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=RNA-free ribonuclease P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            Short=RNA-free RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            EC=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_01078};
DE   AltName: Full=Protein-only RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
GN   OrderedLocusNames=rrnAC2265;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: RNA-free RNase P that catalyzes the removal of the 5'-leader
CC       sequence from pre-tRNA to produce the mature 5'-terminus.
CC       {ECO:0000255|HAMAP-Rule:MF_01078}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01078};
CC   -!- SIMILARITY: Belongs to the HARP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01078}.
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DR   EMBL; AY596297; AAV47094.1; -; Genomic_DNA.
DR   RefSeq; WP_004958916.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5V059; -.
DR   SMR; Q5V059; -.
DR   STRING; 272569.rrnAC2265; -.
DR   EnsemblBacteria; AAV47094; AAV47094; rrnAC2265.
DR   GeneID; 40153160; -.
DR   GeneID; 64824428; -.
DR   KEGG; hma:rrnAC2265; -.
DR   PATRIC; fig|272569.17.peg.2894; -.
DR   eggNOG; arCOG00720; Archaea.
DR   HOGENOM; CLU_109672_0_0_2; -.
DR   OMA; YIIKKPP; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01078; RNA_free_RNase_P; 1.
DR   InterPro; IPR014856; RNA_free_RNase_P.
DR   PANTHER; PTHR41173; PTHR41173; 1.
DR   Pfam; PF08745; PIN_5; 1.
DR   TIGRFAMs; TIGR03875; RNA_lig_partner; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; tRNA processing.
FT   CHAIN           1..224
FT                   /note="RNA-free ribonuclease P"
FT                   /id="PRO_0000366691"
SQ   SEQUENCE   224 AA;  25831 MW;  870B42D1F1B57320 CRC64;
     MVDRPLKQRF VLDTSLFLTP EIRSGDEDLE AACLDLLDLI SEAKLVHNIS CYMPPSIQAE
     LTTMLEDRAI SDEVLTKLDT WVITKSPAHH EVRIPADLVY EFIDEMSERV DRGLRVSEKA
     VRKAEESRAE TVEEHDHMTE VDKVISDLRD EYRDTLRQGV LDSREDFDLL ILAQELDAGV
     VTEDQGIINW AEDFGLRYLK GRNFPPLLRE YLAADDPDRW RDES