ID   RFRNP_HYDS0             Reviewed;         186 AA.
AC   B4U969;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=RNA-free ribonuclease P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            Short=RNA-free RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            EC=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_01078};
DE   AltName: Full=Protein-only RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
GN   OrderedLocusNames=HY04AAS1_0994;
OS   Hydrogenobaculum sp. (strain Y04AAS1).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Hydrogenobaculum;
OC   unclassified Hydrogenobaculum.
OX   NCBI_TaxID=380749;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y04AAS1;
RX   PubMed=19136599; DOI=10.1128/jb.01645-08;
RA   Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA   Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA   Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT   "Complete and draft genome sequences of six members of the Aquificales.";
RL   J. Bacteriol. 191:1992-1993(2009).
CC   -!- FUNCTION: RNA-free RNase P that catalyzes the removal of the 5'-leader
CC       sequence from pre-tRNA to produce the mature 5'-terminus.
CC       {ECO:0000255|HAMAP-Rule:MF_01078}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01078};
CC   -!- SIMILARITY: Belongs to the HARP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01078}.
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DR   EMBL; CP001130; ACG57680.1; -; Genomic_DNA.
DR   RefSeq; WP_012514036.1; NC_011126.1.
DR   AlphaFoldDB; B4U969; -.
DR   SMR; B4U969; -.
DR   STRING; 380749.HY04AAS1_0994; -.
DR   EnsemblBacteria; ACG57680; ACG57680; HY04AAS1_0994.
DR   KEGG; hya:HY04AAS1_0994; -.
DR   eggNOG; COG1458; Bacteria.
DR   HOGENOM; CLU_109672_0_0_0; -.
DR   OMA; YIIKKPP; -.
DR   OrthoDB; 1359470at2; -.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01078; RNA_free_RNase_P; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR014856; RNA_free_RNase_P.
DR   PANTHER; PTHR41173; PTHR41173; 1.
DR   Pfam; PF08745; PIN_5; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
DR   TIGRFAMs; TIGR03875; RNA_lig_partner; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; tRNA processing.
FT   CHAIN           1..186
FT                   /note="RNA-free ribonuclease P"
FT                   /id="PRO_0000366687"
SQ   SEQUENCE   186 AA;  21249 MW;  3BC8003251771145 CRC64;
     MQDNVIIDTS IFTNPNIYKS ISLEQPIDAI EAFIGLTHKS SKKIYMPRTV YIELCKVVDL
     ESIKSRFESS IIIKSPNRCN ITINALALFD FVEDMRIRIN KGLRIAEEFA RDKTQDIQNT
     ISKLREKYKE ALRQGTLDSK EDVDVILLAL ELNGVILSGD EGINSWADKF GIRTVNPLFI
     QEFLSF