RFRNP_METMP
ID RFRNP_METMP Reviewed; 223 AA.
AC Q6LX80;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=RNA-free ribonuclease P {ECO:0000255|HAMAP-Rule:MF_01078};
DE Short=RNA-free RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
DE EC=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_01078};
DE AltName: Full=Protein-only RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
GN OrderedLocusNames=MMP1472;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: RNA-free RNase P that catalyzes the removal of the 5'-leader
CC sequence from pre-tRNA to produce the mature 5'-terminus.
CC {ECO:0000255|HAMAP-Rule:MF_01078}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01078};
CC -!- SIMILARITY: Belongs to the HARP family. {ECO:0000255|HAMAP-
CC Rule:MF_01078}.
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DR EMBL; BX950229; CAF31028.1; -; Genomic_DNA.
DR RefSeq; WP_011171416.1; NC_005791.1.
DR AlphaFoldDB; Q6LX80; -.
DR STRING; 267377.MMP1472; -.
DR EnsemblBacteria; CAF31028; CAF31028; MMP1472.
DR GeneID; 37876067; -.
DR KEGG; mmp:MMP1472; -.
DR PATRIC; fig|267377.15.peg.1508; -.
DR eggNOG; arCOG00720; Archaea.
DR HOGENOM; CLU_109672_0_0_2; -.
DR OMA; YIIKKPP; -.
DR OrthoDB; 68994at2157; -.
DR BioCyc; MMAR267377:MMP_RS07575-MON; -.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01078; RNA_free_RNase_P; 1.
DR InterPro; IPR014856; RNA_free_RNase_P.
DR PANTHER; PTHR41173; PTHR41173; 1.
DR Pfam; PF08745; PIN_5; 1.
DR TIGRFAMs; TIGR03875; RNA_lig_partner; 1.
PE 3: Inferred from homology;
KW Endonuclease; Hydrolase; Nuclease; Reference proteome; tRNA processing.
FT CHAIN 1..223
FT /note="RNA-free ribonuclease P"
FT /id="PRO_0000136082"
SQ SEQUENCE 223 AA; 25673 MW; E29E9E22A06242A7 CRC64;
MQKQRFCLDT TAITDSDVRK SLGVSNISES AEKIMDIIAQ ARVQLDISCH IPYDTVYKEL
VGFLTREGCA PETLIKVDTW LVKKTPNRYE IKIPAEIFYE YIKDLRERIN KGMRISENAM
YETALEAYIL SKPDEKDRED VLNEVLSKTV NSFRVKYRNA LRGGTLDSAP DLDVLLLAKE
LDAAVVANDE GIEKWAQRLG LRFVNARDFP FILQEYLDLW DKK