ID   RFRNP_THEKO             Reviewed;         198 AA.
AC   Q5JH27;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=RNA-free ribonuclease P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            Short=RNA-free RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
DE            EC=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_01078};
DE   AltName: Full=Protein-only RNase P {ECO:0000255|HAMAP-Rule:MF_01078};
GN   OrderedLocusNames=TK1425;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: RNA-free RNase P that catalyzes the removal of the 5'-leader
CC       sequence from pre-tRNA to produce the mature 5'-terminus.
CC       {ECO:0000255|HAMAP-Rule:MF_01078}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01078};
CC   -!- SIMILARITY: Belongs to the HARP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01078}.
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DR   EMBL; AP006878; BAD85614.1; -; Genomic_DNA.
DR   RefSeq; WP_011250376.1; NC_006624.1.
DR   AlphaFoldDB; Q5JH27; -.
DR   SMR; Q5JH27; -.
DR   STRING; 69014.TK1425; -.
DR   EnsemblBacteria; BAD85614; BAD85614; TK1425.
DR   GeneID; 3235451; -.
DR   KEGG; tko:TK1425; -.
DR   PATRIC; fig|69014.16.peg.1386; -.
DR   eggNOG; arCOG00720; Archaea.
DR   HOGENOM; CLU_109672_0_0_2; -.
DR   InParanoid; Q5JH27; -.
DR   OMA; YIIKKPP; -.
DR   OrthoDB; 68994at2157; -.
DR   PhylomeDB; Q5JH27; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01078; RNA_free_RNase_P; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR014856; RNA_free_RNase_P.
DR   PANTHER; PTHR41173; PTHR41173; 1.
DR   Pfam; PF08745; PIN_5; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
DR   TIGRFAMs; TIGR03875; RNA_lig_partner; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; tRNA processing.
FT   CHAIN           1..198
FT                   /note="RNA-free ribonuclease P"
FT                   /id="PRO_0000366696"
SQ   SEQUENCE   198 AA;  22949 MW;  B05E1565D94AB570 CRC64;
     MKFVLDTSIF VNPEVRKNFG DNPTEAMKTF LSYAEKLFGK VEFYMPPGIY REVMHFVDSE
     ELRPAIELYI IKKPPNVHEL KIPAFVVYEL IEDIRRRIDK GLRVAEKAVR ESVLDTDNVD
     NIIQKLRRNY RRALREGIVD SKEDFELILL AMELDATIVS ADVGILTWAQ KMGIKWVDSS
     VFREVLEGLV EKLEGKNL