RFS1_CAEEL
ID RFS1_CAEEL Reviewed; 245 AA.
AC P34348;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=RAD51-like protein 1;
GN Name=rfs-1; ORFNames=C30A5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP INTERACTION WITH RAD-51.
RX PubMed=11778048; DOI=10.1126/science.1065986;
RA Boulton S.J., Gartner A., Reboul J., Vaglio P., Dyson N., Hill D.E.,
RA Vidal M.;
RT "Combined functional genomic maps of the C. elegans DNA damage response.";
RL Science 295:127-131(2002).
RN [4]
RP INTERACTION WITH BRC-2.
RX PubMed=15798199; DOI=10.1128/mcb.25.8.3127-3139.2005;
RA Martin J.S., Winkelmann N., Petalcorin M.I., McIlwraith M.J., Boulton S.J.;
RT "RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-
RT related protein during DNA double-strand break repair.";
RL Mol. Cell. Biol. 25:3127-3139(2005).
RN [5]
RP FUNCTION.
RX PubMed=17611606; DOI=10.1038/sj.emboj.7601766;
RA Ward J.D., Barber L.J., Petalcorin M.I., Yanowitz J., Boulton S.J.;
RT "Replication blocking lesions present a unique substrate for homologous
RT recombination.";
RL EMBO J. 26:3384-3396(2007).
CC -!- FUNCTION: Has a role in the homologous recombination repair (HRR) of
CC genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA
CC gaps generated at stalled replication fork barriers.
CC {ECO:0000269|PubMed:17611606}.
CC -!- SUBUNIT: Interacts with brc-2 and rad-51. {ECO:0000269|PubMed:11778048,
CC ECO:0000269|PubMed:15798199}.
CC -!- INTERACTION:
CC P34348; Q95Q25: rad-51; NbExp=3; IntAct=EBI-330791, EBI-321895;
CC P34348; Q21621: rip-1; NbExp=4; IntAct=EBI-330791, EBI-332336;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; FO080290; CCD62651.1; -; Genomic_DNA.
DR PIR; S44775; S44775.
DR RefSeq; NP_001293630.1; NM_001306701.1.
DR AlphaFoldDB; P34348; -.
DR SMR; P34348; -.
DR IntAct; P34348; 2.
DR MINT; P34348; -.
DR STRING; 6239.C30A5.2; -.
DR PaxDb; P34348; -.
DR EnsemblMetazoa; C30A5.2.1; C30A5.2.1; WBGene00004342.
DR EnsemblMetazoa; C30A5.2.2; C30A5.2.2; WBGene00004342.
DR WormBase; C30A5.2; CE00094; WBGene00004342; rfs-1.
DR eggNOG; ENOG502T0IA; Eukaryota.
DR GeneTree; ENSGT00940000159095; -.
DR HOGENOM; CLU_987747_0_0_1; -.
DR InParanoid; P34348; -.
DR OMA; HITHWRG; -.
DR OrthoDB; 1394413at2759; -.
DR PhylomeDB; P34348; -.
DR PRO; PR:P34348; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004342; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0033061; C:DNA recombinase mediator complex; IDA:WormBase.
DR GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IPI:WormBase.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000730; P:DNA recombinase assembly; IGI:CACAO.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IGI:WormBase.
DR GO; GO:0042148; P:strand invasion; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR Pfam; PF08423; Rad51; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 1: Evidence at protein level;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..245
FT /note="RAD51-like protein 1"
FT /id="PRO_0000065204"
SQ SEQUENCE 245 AA; 28104 MW; 28BEFBEA9F7A026F CRC64;
MDPSENVFKY ETAYDLLVRL GAERLFLRTC LSILDPVLEL HPGKCYEIDG DLGVGKTQIC
YSFAAKFLQT KKTAKMGWIG ATPLRTDHLL LHIEHFGNQT NEDILDRIVC KRVEKIAELQ
DSLTRFLDTI NLQLVIVENI DAILHDTVYH KEMGRSMQSD VVERIRKLTK LEITVILTNH
ITHWRGYPAP ALGAFWSSQI NNRFFIEKRN DDSDIRIVSA MKGEQDDGMN RIEFKIGDRG
LKAVE
