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RFS1_YEAST
ID   RFS1_YEAST              Reviewed;         210 AA.
AC   P38234; D6VQ51;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Protein RFS1;
DE   AltName: Full=RAD55 suppressor protein 1;
GN   Name=RFS1; OrderedLocusNames=YBR052C; ORFNames=YBR0505;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7597852; DOI=10.1002/yea.320110511;
RA   Aljinovic G., Pohl T.M.;
RT   "Sequence and analysis of 24 kb on chromosome II of Saccharomyces
RT   cerevisiae.";
RL   Yeast 11:475-479(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   GENE NAME.
RX   PubMed=16782999; DOI=10.1534/genetics.106.058685;
RA   Valencia-Burton M., Oki M., Johnson J., Seier T.A., Kamakaka R.,
RA   Haber J.E.;
RT   "Different mating-type-regulated genes affect the DNA repair defects of
RT   Saccharomyces RAD51, RAD52 and RAD55 mutants.";
RL   Genetics 174:41-55(2006).
RN   [8]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19064668; DOI=10.1083/jcb.200806035;
RA   Grossmann G., Malinsky J., Stahlschmidt W., Loibl M., Weig-Meckl I.,
RA   Frommer W.B., Opekarova M., Tanner W.;
RT   "Plasma membrane microdomains regulate turnover of transport proteins in
RT   yeast.";
RL   J. Cell Biol. 183:1075-1088(2008).
CC   -!- INTERACTION:
CC       P38234; Q12335: PST2; NbExp=4; IntAct=EBI-21445, EBI-14064;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Membrane
CC       raft {ECO:0000269|PubMed:19064668}.
CC   -!- MISCELLANEOUS: Present with 7060 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the WrbA family. {ECO:0000305}.
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DR   EMBL; Z35921; CAA84995.1; -; Genomic_DNA.
DR   EMBL; Z46260; CAA86395.1; -; Genomic_DNA.
DR   EMBL; AY557709; AAS56035.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07171.1; -; Genomic_DNA.
DR   PIR; S45910; S45910.
DR   RefSeq; NP_009608.1; NM_001178400.1.
DR   AlphaFoldDB; P38234; -.
DR   SMR; P38234; -.
DR   BioGRID; 32753; 63.
DR   DIP; DIP-1761N; -.
DR   IntAct; P38234; 33.
DR   MINT; P38234; -.
DR   STRING; 4932.YBR052C; -.
DR   iPTMnet; P38234; -.
DR   MaxQB; P38234; -.
DR   PaxDb; P38234; -.
DR   PRIDE; P38234; -.
DR   EnsemblFungi; YBR052C_mRNA; YBR052C; YBR052C.
DR   GeneID; 852341; -.
DR   KEGG; sce:YBR052C; -.
DR   SGD; S000000256; RFS1.
DR   VEuPathDB; FungiDB:YBR052C; -.
DR   eggNOG; KOG3135; Eukaryota.
DR   GeneTree; ENSGT00940000176381; -.
DR   HOGENOM; CLU_051402_0_1_1; -.
DR   InParanoid; P38234; -.
DR   OMA; TTPYIAH; -.
DR   BioCyc; YEAST:G3O-29023-MON; -.
DR   PRO; PR:P38234; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38234; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Protein RFS1"
FT                   /id="PRO_0000200767"
FT   DOMAIN          4..203
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
SQ   SEQUENCE   210 AA;  22921 MW;  D86CA1C0FE4B7CAD CRC64;
     MPKVAILIYS VDDIIATLAE NEKKGIEIAG GEAEIFQVPD VSYKTEYATE EGKEAAKVAK
     TNADFSYKIL TRETLVEYDY YLFGIPTKFG NFPAEWKSFW DSNTGGLWAK GSLHGKIAGL
     FVSGAISGKG DTEMCIMNAM STLVHHGVIY VPLGYKNAYK ELTDVEDVNG SCAWGAGCVS
     GIDGGRPPSL SELRVHQLQG KAFYDRIKDL
 
 
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