ID   RFT1_ASHGO              Reviewed;         552 AA.
AC   Q754Q7;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Oligosaccharide translocation protein RFT1;
GN   Name=RFT1; OrderedLocusNames=AFR015W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May participate in the translocation of oligosaccharide from
CC       the cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53386.1; -; Genomic_DNA.
DR   RefSeq; NP_985562.1; NM_210916.2.
DR   AlphaFoldDB; Q754Q7; -.
DR   SMR; Q754Q7; -.
DR   STRING; 33169.AAS53386; -.
DR   EnsemblFungi; AAS53386; AAS53386; AGOS_AFR015W.
DR   GeneID; 4621801; -.
DR   KEGG; ago:AGOS_AFR015W; -.
DR   eggNOG; KOG2864; Eukaryota.
DR   HOGENOM; CLU_023360_3_0_1; -.
DR   InParanoid; Q754Q7; -.
DR   OMA; WPGKLFG; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR   InterPro; IPR007594; RFT1.
DR   PANTHER; PTHR13117; PTHR13117; 1.
DR   Pfam; PF04506; Rft-1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..552
FT                   /note="Oligosaccharide translocation protein RFT1"
FT                   /id="PRO_0000212414"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        512..532
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   552 AA;  62449 MW;  33F80D6FB9BACBBE CRC64;
     MCSTGEEILA KSTQGATFLM MGQLFGKLVT FVLHNVLVRF LSPRIFGITS FLDFLSSTVL
     FFSREAIRLA TLRIKTGGDG GRGGEMSAEL QTAVNFANIP MCIGAPLAVV LAVWQYSNLN
     SYFTQLPFFS WSIYLVLLSI LAELASEPLY VVNQFMLNYR KRSQFEGAAV AASCLVNFAV
     IYWYENWVNG RGETVHDSYK QEGIAVLAFA LGKVARAMTL LALYYVDYVR HLAHEKLFSL
     SLTKVRVPGS VYTAYFDSDV LQHFKKVYFQ LCFKHLLTEG DKLIINSLCT VEEQGIYSLL
     SNYGSLITRM VFAPIEESLL LFLTRLLSDK TQQNLHICMR VLVNLVKFYL YLALVIVIFG
     PTNSSFLLKF LIGSKWSSTS VLETIRVYCF YLPFLSMNGI LEAFFASVAS GDEILRHSYL
     MMLLSGVFLL NCWVFLAHFN LSLEGLIFSN IINMTLRIIY CSNYIRGFYK RLFADSKQTS
     LSSSFAGLKK ILLLCIVVAY VDWSIIGYVQ NIRQLLVNIL LSVTLVLAMA YNERKLLLEF
     IKKSKPVPVK EN