ID   RFT1_CAEEL              Reviewed;         522 AA.
AC   Q23444; Q86DD6; U4PBU5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Protein RFT1 homolog;
GN   Name=rfth-1 {ECO:0000312|WormBase:ZK180.3a};
GN   ORFNames=ZK180.3 {ECO:0000312|WormBase:ZK180.3a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May be involved in N-linked oligosaccharide assembly.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a {ECO:0000312|WormBase:ZK180.3a};
CC         IsoId=Q23444-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:ZK180.3b};
CC         IsoId=Q23444-2; Sequence=VSP_029511;
CC       Name=c {ECO:0000312|WormBase:ZK180.3c};
CC         IsoId=Q23444-3; Sequence=VSP_053991;
CC   -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR   EMBL; BX284604; CCD73072.1; -; Genomic_DNA.
DR   EMBL; BX284604; CCD73073.2; -; Genomic_DNA.
DR   EMBL; BX284604; CDH93204.1; -; Genomic_DNA.
DR   PIR; T29705; T29705.
DR   RefSeq; NP_001023610.1; NM_001028439.3. [Q23444-1]
DR   RefSeq; NP_001023611.2; NM_001028440.4.
DR   RefSeq; NP_001294434.1; NM_001307505.1.
DR   AlphaFoldDB; Q23444; -.
DR   STRING; 6239.ZK180.3a; -.
DR   EPD; Q23444; -.
DR   PaxDb; Q23444; -.
DR   PeptideAtlas; Q23444; -.
DR   EnsemblMetazoa; ZK180.3a.1; ZK180.3a.1; WBGene00022677. [Q23444-1]
DR   EnsemblMetazoa; ZK180.3b.1; ZK180.3b.1; WBGene00022677. [Q23444-2]
DR   EnsemblMetazoa; ZK180.3c.1; ZK180.3c.1; WBGene00022677. [Q23444-3]
DR   GeneID; 177216; -.
DR   KEGG; cel:CELE_ZK180.3; -.
DR   UCSC; ZK180.3a; c. elegans. [Q23444-1]
DR   CTD; 177216; -.
DR   WormBase; ZK180.3a; CE07621; WBGene00022677; rfth-1. [Q23444-1]
DR   WormBase; ZK180.3b; CE48802; WBGene00022677; rfth-1. [Q23444-2]
DR   WormBase; ZK180.3c; CE48641; WBGene00022677; rfth-1. [Q23444-3]
DR   eggNOG; KOG2864; Eukaryota.
DR   GeneTree; ENSGT00390000011390; -.
DR   HOGENOM; CLU_023360_5_0_1; -.
DR   InParanoid; Q23444; -.
DR   OMA; WPGKLFG; -.
DR   OrthoDB; 582756at2759; -.
DR   PhylomeDB; Q23444; -.
DR   PRO; PR:Q23444; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00022677; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR   InterPro; IPR007594; RFT1.
DR   PANTHER; PTHR13117; PTHR13117; 1.
DR   Pfam; PF04506; Rft-1; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..522
FT                   /note="Protein RFT1 homolog"
FT                   /id="PRO_0000311289"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..379
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_053991"
FT   VAR_SEQ         1..148
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_029511"
SQ   SEQUENCE   522 AA;  58155 MW;  14C0196D6D23E8CE CRC64;
     MSLFSSLVHN VRGQLIARII SFAINMYLLR RINNDVLGLV NVRLTLLYSS ILFLTREPLR
     KAEIIRGSLP KFINLLWLSP IISTVISVVC VYLWYAFSST SDEVSWSVLL SFPISAIIES
     IAEPFSVISL RLESKCGSLA QHFAIGQGML ICVKRIFVLA GLFMFPGMYH LELFAYAQYI
     GAIAYLLFNF VAFYIYIRNK SIPELEQFST FSDLFPKFSE GIDRDSIHAV FTMFSHSILK
     QLLTDGSAYV MTFTELLSLK DQAVYDAVER VGSIIVRTIL SPIDENCNAY FSNTIRKESS
     VFNKNTDNHD DLVDTLSKVL HVVGVIGFVA CTFGIPYSPV VISLYGGKLL SENGGALLLS
     LYSGYILVTA INGITEGFAM ASMDNRQIFT HGKFLFVTSI IHLIINYVLC VYMNSAGFIV
     ANIINMSVRI IYNWRTIREY LGDKCPSFTE VLPTGQTSIF LGVSLLATSF TYLLFATTPG
     LSYTLAHIAI GAVCLILTAQ DTAQHDSVFT VIVDSLAKKH RD