ID   RFT1_CANAL              Reviewed;         561 AA.
AC   Q5A6N8; A0A1D8PSP3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Oligosaccharide translocation protein RFT1;
GN   Name=RFT1; OrderedLocusNames=CAALFM_CR04280CA;
GN   ORFNames=CaO19.516, CaO19.8147;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: May participate in the translocation of oligosaccharide from
CC       the cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31166.1; -; Genomic_DNA.
DR   RefSeq; XP_717379.1; XM_712286.1.
DR   AlphaFoldDB; Q5A6N8; -.
DR   STRING; 237561.Q5A6N8; -.
DR   GeneID; 3640993; -.
DR   KEGG; cal:CAALFM_CR04280CA; -.
DR   CGD; CAL0000185017; orf19.8147.
DR   VEuPathDB; FungiDB:CR_04280C_A; -.
DR   eggNOG; KOG2864; Eukaryota.
DR   HOGENOM; CLU_023360_3_0_1; -.
DR   InParanoid; Q5A6N8; -.
DR   OrthoDB; 582756at2759; -.
DR   PRO; PR:Q5A6N8; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR   InterPro; IPR007594; RFT1.
DR   PANTHER; PTHR13117; PTHR13117; 1.
DR   Pfam; PF04506; Rft-1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..561
FT                   /note="Oligosaccharide translocation protein RFT1"
FT                   /id="PRO_0000212415"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   561 AA;  64386 MW;  509B006373F52252 CRC64;
     MSVSSSKQPG NDANDANSSV KGVSHLIIVQ IIAKLLTFVL NQLIIRYLSP SIIGVTTYLE
     FICSTILFFS RESIRLSVQR VRNNSDNKDY VAQKVVNFGI LAIAFAFPIF MVIGYWQLNY
     SSVMDKLFVS PFYKPVIVLF VASVILELLV EPIYCLYQFQ LDFGKRSKFE GSAIFVKCIV
     SVLSILLARQ YFVDQKFEGV AICAFALAQF SYSLTLFACY LMSFRFEFQN NKINYNLVKL
     KDENAREFYF EQDTLTIVKG FFVQMIFKQF LTEGDKLLIS HLCTIEEQGM YAVMANYGSI
     IARLLFQPLE ESTRLMFTKL LNENTRSQGD EKPQKSESHK CMQTFNYLKL ISIFYFNLSL
     IILFAGVTSG PYLLKLLMGG RASNWESTDI FKLFPQYVVY LPFLAFNGIL EALFSSMATN
     SDLKNFSKFM TLITILVLIF SYLLIDVLNL RISGLILANV FNMSSRIGYC YFKISKFYSK
     ENVKVSFVDI VRYSCPSILI TSIIWIIQLF IIGKNTTNFV QLILNACFSF VLVIILMVME
     RKNSKKPFEK VTNKFMKPKL D