RFT1_DICDI
ID RFT1_DICDI Reviewed; 540 AA.
AC Q54IV7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Protein RFT1 homolog;
GN Name=rft1; ORFNames=DDB_G0288491;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in N-linked oligosaccharide assembly.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR EMBL; AAFI02000112; EAL63194.1; -; Genomic_DNA.
DR RefSeq; XP_636696.1; XM_631604.1.
DR AlphaFoldDB; Q54IV7; -.
DR SMR; Q54IV7; -.
DR STRING; 44689.DDB0305027; -.
DR PaxDb; Q54IV7; -.
DR EnsemblProtists; EAL63194; EAL63194; DDB_G0288491.
DR GeneID; 8626653; -.
DR KEGG; ddi:DDB_G0288491; -.
DR dictyBase; DDB_G0288491; rft1.
DR eggNOG; KOG2864; Eukaryota.
DR HOGENOM; CLU_023360_5_0_1; -.
DR InParanoid; Q54IV7; -.
DR OMA; WPGKLFG; -.
DR PhylomeDB; Q54IV7; -.
DR PRO; PR:Q54IV7; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR InterPro; IPR007594; RFT1.
DR PANTHER; PTHR13117; PTHR13117; 1.
DR Pfam; PF04506; Rft-1; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..540
FT /note="Protein RFT1 homolog"
FT /id="PRO_0000328237"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 321..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 487
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 540 AA; 61896 MW; D5EB7F70479D067D CRC64;
MKQPQTESNV LKNGLVGAFY LIGLQIISRL FTFIINTLVI VGVDDSIFGV SAIQYQLLSS
IILFLSREAI RRACTRVNIT DKLNNDNNLK SVINLSWLVL PIGIGLSIIF ENFFLYTSTK
ETLEILNYHY GLRLFTISSI LELLSEPMYI LAQNLLLFKI RTTVEGFALF FKTFSTYYFI
VILNMGLIGF GYAQILYSLT LVIGYFGYFL INIINNNKNK DNKEFSNCFK SIDQLFPKFS
TRIDRNLIKL SLLYTWQSIY KLLLQEGEKF VLFFSETNQG QAIFAIVSNL GSLIVRFLFL
PIEETCFLMF PKLFPTINNN NNNNNNNNNN NNNNNKNQEN NNNNDDFKNG ANVLIVIMKF
LILVSLVFTC FGPGFSHLLL NLLYNNKFRD TNAGVLLGFY CIYVGFLAIN GVSESFVHSV
AKEDQLKTVN WVLIIIGFIY LLFTLIFCKL FQNIGIILAN CLNIKLSNMI PNKMVLLSFI
ISFIITNLSN KYIYNAVSFK STCIHLLIGI ICFIQTCTFI YLKEWVSIKE FKKILSNKNK
