RFT1_KLULA
ID RFT1_KLULA Reviewed; 556 AA.
AC P40913; Q6CNR7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Oligosaccharide translocation protein RFT1;
GN Name=RFT1; OrderedLocusNames=KLLA0E10439g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-417.
RX PubMed=7845362; DOI=10.1007/bf00279755;
RA Mulder W., Scholten I.H.J.M., de Boer R.W., Grivell L.A.;
RT "Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts
RT the presence of a novel 4-cysteine zinc-finger motif.";
RL Mol. Gen. Genet. 245:96-106(1994).
CC -!- FUNCTION: May participate in the translocation of oligosaccharide from
CC the cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR EMBL; CR382125; CAG99509.1; -; Genomic_DNA.
DR EMBL; L25779; AAC41661.1; -; Genomic_DNA.
DR PIR; S51564; S51564.
DR RefSeq; XP_454422.1; XM_454422.1.
DR AlphaFoldDB; P40913; -.
DR SMR; P40913; -.
DR STRING; 28985.XP_454422.1; -.
DR EnsemblFungi; CAG99509; CAG99509; KLLA0_E10451g.
DR GeneID; 2894284; -.
DR KEGG; kla:KLLA0_E10451g; -.
DR eggNOG; KOG2864; Eukaryota.
DR HOGENOM; CLU_023360_3_0_1; -.
DR InParanoid; P40913; -.
DR OMA; WPGKLFG; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0034203; P:glycolipid translocation; IEA:EnsemblFungi.
DR InterPro; IPR007594; RFT1.
DR PANTHER; PTHR13117; PTHR13117; 1.
DR Pfam; PF04506; Rft-1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..556
FT /note="Oligosaccharide translocation protein RFT1"
FT /id="PRO_0000212417"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 330..336
FT /note="RLLSVSS -> ALLRLCC (in Ref. 2; AAC41661)"
FT /evidence="ECO:0000305"
FT CONFLICT 415..417
FT /note="SGD -> PVI (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 556 AA; 64214 MW; AB9E0E7691EA5300 CRC64;
MNVKNEHMNK FANGVLFLML GQTLSKGVNF LLNTLLVRYL SPRIFGITSF LEFLLSTVLF
FSRESIRIST LRIKSTTDSG KLEKVEDGED TRTLQSLINF GYIPFVIGLP LSIILISWQY
SNLNSYFIDL PYFKASIFLI WLSILIELVS EPFYLVHQYL LNHFIRSKYE SLGVTFACVA
NFIIVVWFEK MVNGVGLELH DDYKQEGIAI FAFAVGKLVH AMTLLACYSY NYYSEVYTTG
ERYSYKLTKI RPETRQESYY FQNDTVQHFK KVYFQLCFKH LLTEGDKLII NSLCTVEEQG
IYSLLSNYGS LITRLLFAPI EEALRLFLAR LLSVSSKKNL WLSMKVLIDL TKFYLYLSLF
IIIFGPINSS YLLKFVIGSK WSSTSFLETI RTYCFYIPFL SLNGIFEAFF QSVASGDQIF
KHSYVMMLFS GIFLFNCWLF IEYFDLSLEG LIVSNILNMA LRIAYCGNFI HKFYHYLLKE
SSTETTQSIL PNISTFKNVA LIAAIIGALD WYFIGYVENM RELLINVILA LLLLILVIYK
EKSLISELLA AKTYAA
