RFT1_SCHPO
ID RFT1_SCHPO Reviewed; 527 AA.
AC O94302;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Oligosaccharide translocation protein rft1;
GN Name=rft1; ORFNames=SPBC887.19;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May participate in the translocation of oligosaccharide from
CC the cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21904.1; -; Genomic_DNA.
DR PIR; T40744; T40744.
DR RefSeq; NP_596493.1; NM_001022413.2.
DR AlphaFoldDB; O94302; -.
DR STRING; 4896.SPBC887.19.1; -.
DR iPTMnet; O94302; -.
DR SwissPalm; O94302; -.
DR MaxQB; O94302; -.
DR PaxDb; O94302; -.
DR PRIDE; O94302; -.
DR EnsemblFungi; SPBC887.19.1; SPBC887.19.1:pep; SPBC887.19.
DR GeneID; 2541221; -.
DR KEGG; spo:SPBC887.19; -.
DR PomBase; SPBC887.19; rft1.
DR VEuPathDB; FungiDB:SPBC887.19; -.
DR eggNOG; KOG2864; Eukaryota.
DR HOGENOM; CLU_023360_3_1_1; -.
DR InParanoid; O94302; -.
DR OMA; WPGKLFG; -.
DR PhylomeDB; O94302; -.
DR PRO; PR:O94302; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; ISS:PomBase.
DR GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR InterPro; IPR007594; RFT1.
DR PANTHER; PTHR13117; PTHR13117; 1.
DR Pfam; PF04506; Rft-1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..527
FT /note="Oligosaccharide translocation protein rft1"
FT /id="PRO_0000212418"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 527 AA; 59773 MW; 2E7A5A97EA494610 CRC64;
MDKSDSLLQS SSKGLRSSIF FQGSSRILTF FLNQLTIRLT SPSAYAFSSI HFEILQSTIL
FLSRESVRLA MQRIPSENAI ITSTSTESNK SKKLSDQLQL IKNTSLISVY IGIVISLLVS
LFYFYSLPNF PYSKTCIFIY TVSSFIELLS EPYYEVLQWR QKFSKTASAE GLGTIICSLL
SFAISVLGRN KAPSSLPFAL GNLSEKVTIF FTLRYFAKQP FSIFLHKVGE NERYIFWDSS
TLRIICSHTY QVLLKHLITK GDKIMVAWYA SPSAQGPYAL ASNYGSLLAR IVFRPVEDHS
HIVFAQLTHY KNKKDEKKAL NLLAWILKLY SYMSLFILFG SNYSDIVLLF GAGSKWASPD
SSSILSWYAM YIPFMAANGV LEAFYVSAAN SSQLYDQGKC YLASAVFYFI TGKFLLSWFN
LGSHGLILAN ILNLSLRICF ALRFILHNYK DFSLPRSLPR PFLLALSILL SIISSFLVKH
WRESKVPFLV YFLSAPSLAI LYSCFIILVD KDVRGYAKIL LSKYYIK
