ID   RFT1_XENTR              Reviewed;         539 AA.
AC   Q0D2E8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein RFT1 homolog;
GN   Name=rft1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in N-linked oligosaccharide assembly. May
CC       participate in the translocation of oligosaccharide from the
CC       cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC       membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR   EMBL; BC121860; AAI21861.1; -; mRNA.
DR   RefSeq; NP_001072828.1; NM_001079360.1.
DR   AlphaFoldDB; Q0D2E8; -.
DR   SMR; Q0D2E8; -.
DR   STRING; 8364.ENSXETP00000060331; -.
DR   PaxDb; Q0D2E8; -.
DR   DNASU; 780289; -.
DR   Ensembl; ENSXETT00000061490; ENSXETP00000060331; ENSXETG00000031244.
DR   GeneID; 780289; -.
DR   KEGG; xtr:780289; -.
DR   CTD; 91869; -.
DR   Xenbase; XB-GENE-1015143; rft1.
DR   eggNOG; KOG2864; Eukaryota.
DR   HOGENOM; CLU_023360_5_0_1; -.
DR   InParanoid; Q0D2E8; -.
DR   OMA; WPGKLFG; -.
DR   OrthoDB; 582756at2759; -.
DR   PhylomeDB; Q0D2E8; -.
DR   TreeFam; TF313129; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000031244; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR   InterPro; IPR007594; RFT1.
DR   PANTHER; PTHR13117; PTHR13117; 1.
DR   Pfam; PF04506; Rft-1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..539
FT                   /note="Protein RFT1 homolog"
FT                   /id="PRO_0000311288"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  60808 MW;  04ABA6395D85E3ED CRC64;
     MGSQEVLMDA TKLASYSVIL QILFRVLTFA LNAFTLRYVS KEIIGIVNVR LTLFYTTVVF
     LAREAFRRAC LSHSAQQSWR HTIHLTWLAV PLGICWSFIL GWIWLQILEV PEPEAIPYYN
     IGVWAFGFSA VVELLAEPFW VLAQAHLFVK LKVVAESLAI IIRCSVTVIL VLLCPQWGLL
     IFSLAQVLYT SALALCYIAY FARFLGSLEA EKKPFPLRRM REFLPRFSSS QAFLDWKQAW
     LAWSFFKQSF LKQILTEGER YVMTFLNVLS FGDQGVYDIV NNLGSLVARF IFLPIEESFY
     VFFAKVLERG KKVQSQRKEE ISMASEVLES LLKLVTLIGL VIIAFGYAYS HLALDIYGGS
     MLSGGSGPVL LRCYCLYVLL LAINGVTECF TFASMGKEDV DRYNYVMLGL SLSFLCLSYY
     MTLWLGSVGF ILANCFNMGL RITHSLLYIM RYYKGSPYQP LIGLLPSPVV VCVLAVSAAV
     TGYSEVALCC DKGWLLCLGH IVVGGLCLLV TLGAAVLSEK KLTHFIRSHL LSRHQRKEQ