ID   RFT1_YARLI              Reviewed;         673 AA.
AC   Q6C6S3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Oligosaccharide translocation protein RFT1;
GN   Name=RFT1; OrderedLocusNames=YALI0E06721g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May participate in the translocation of oligosaccharide from
CC       the cytoplasmic side to the lumenal side of the endoplasmic reticulum
CC       membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RFT1 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79221.1; -; Genomic_DNA.
DR   RefSeq; XP_503639.1; XM_503639.1.
DR   AlphaFoldDB; Q6C6S3; -.
DR   SMR; Q6C6S3; -.
DR   STRING; 4952.CAG79221; -.
DR   EnsemblFungi; CAG79221; CAG79221; YALI0_E06721g.
DR   GeneID; 2912408; -.
DR   KEGG; yli:YALI0E06721g; -.
DR   VEuPathDB; FungiDB:YALI0_E06721g; -.
DR   HOGENOM; CLU_023360_3_0_1; -.
DR   InParanoid; Q6C6S3; -.
DR   OMA; WPGKLFG; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0034203; P:glycolipid translocation; IBA:GO_Central.
DR   InterPro; IPR007594; RFT1.
DR   PANTHER; PTHR13117; PTHR13117; 1.
DR   Pfam; PF04506; Rft-1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..673
FT                   /note="Oligosaccharide translocation protein RFT1"
FT                   /id="PRO_0000212419"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        486..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        524..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        550..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        588..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        613..633
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  73246 MW;  273C544DE5F2CC00 CRC64;
     MDELPSHEPK NRYSRSSSIG SPADARYAPP SPLHEPSDAS QIAIAMGGVR QRSASIRKHR
     RQQPSQVFIP PMHENVTAPR DEHEPKMSSP VPETDEKPLL QTSAAGATLL IGIQILSKLA
     SFGLNQMLLL VATPALFGAN AQLEFVLNTV LFFSREAVRL ALQRLTLAGK KPDVYVFGGG
     VVQDTVSGTS QAVINMGYIS VLLGVFFSSV AAASHSLFSV AYASWAVQLV CIAAMVDLAS
     EPYYVLAMQQ LRFRSRAAAE AVAILVRCVV TFSFTLLAKD TDGGLNGGVL AFAFGQLAYS
     LISSAVYIYT VRQDNRDRQF SFRPQKIQPF ESQMEMSDNN RDVITHNASP YYLDKPTVRL
     AGSIWIQTVF KHCLTEGDRI LVSYFLPLYD QGVYAIVLNY GSLVARIVFF PIEEGLRTFF
     SNLLGEKPSE TALKLSRQVL CSVVRIYTYV ALFAAGFGPT TLPFIFGTLL GARGGQWSEG
     APSRSAPAVM GAFALYIPFM ALNGALESFV QSVATPADLR RQAVALGVFS VVFATVGGLL
     MKTMDLGARG LVFANIVNMT LRIGWSVVFI YHYYVSHKAE NVNPTHLLPG KLVIATGVTT
     ILASLFGVGR VSSFRDVGIN IGLALALAAA IAVEERQALV QLVQLVRKKE DKVKVDDKEE
     KEKESDKSEG ESE