ID   RFTN1_CHICK             Reviewed;         602 AA.
AC   Q7SZI5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Raftlin;
DE   AltName: Full=Raft-linking protein;
GN   Name=RFTN1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=12805216; DOI=10.1093/emboj/cdg293;
RA   Saeki K., Miura Y., Aki D., Kurosaki T., Yoshimura A.;
RT   "The B cell-specific major raft protein, Raftlin, is necessary for the
RT   integrity of lipid raft and BCR signal transduction.";
RL   EMBO J. 22:3015-3026(2003).
CC   -!- FUNCTION: May play a pivotal role in the formation and/or maintenance
CC       of lipid rafts. May regulate B-cell antigen receptor-mediated
CC       signaling. {ECO:0000269|PubMed:12805216}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}. Note=Associates with lipid rafts. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the raftlin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB092511; BAC78491.1; -; mRNA.
DR   RefSeq; NP_989789.1; NM_204458.1.
DR   AlphaFoldDB; Q7SZI5; -.
DR   STRING; 9031.ENSGALP00000043108; -.
DR   PaxDb; Q7SZI5; -.
DR   PRIDE; Q7SZI5; -.
DR   GeneID; 395109; -.
DR   KEGG; gga:395109; -.
DR   CTD; 23180; -.
DR   VEuPathDB; HostDB:geneid_395109; -.
DR   eggNOG; ENOG502QVP2; Eukaryota.
DR   InParanoid; Q7SZI5; -.
DR   OrthoDB; 434232at2759; -.
DR   PhylomeDB; Q7SZI5; -.
DR   PRO; PR:Q7SZI5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028169; Raftlin.
DR   PANTHER; PTHR17601; PTHR17601; 1.
DR   Pfam; PF15250; Raftlin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Lipoprotein; Membrane; Myristate; Palmitate;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..602
FT                   /note="Raftlin"
FT                   /id="PRO_0000251955"
FT   REGION          178..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   LIPID           3
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   602 AA;  65696 MW;  0D1EF9C453142168 CRC64;
     MGCGLNKLEK HDEKRPGNIY STLKRPQVET KIDVSYEYRF LDFTTLNDAE LPGSSAIKLS
     SLRDLPAQLQ ELYQQGFVLA AVHPFVQPTD EKEKTPQEQI FRAVLIKKTE RSPKGGIHSE
     GYILEVECCS SVNQLSDKKE IPDFIKKIQD AASQGLKFVG IIPQYHSQKN CLVSSSLTPA
     SNNSVQSRDN KNVSNCPEDH ASLDGEKIDG INGCSTPAPG EENADQCATS REGRKGEGQA
     AEEPDCKSAK GSKEQHEHPG GREAPDTQNG VAENETPARC SKPLTDKTEI FTLFNKPKTP
     QRCSQYYTVT IPMRISRNGQ TVNSLEANWL EHMTDHFRKG GSLVNAIFSL GMVNDSLHGT
     MDGVFLFEDV AVEDNKTTQG YDAIVVEQWT VLKGVEVQTD YVPLLNSLAI YGWQLTCVLP
     TPIVKTNREG NLSTKQIVFL QRPSLPQKAK KKESKFHWRF SKEDMHNKPM KKSRKTKLSS
     GEKQTAEKQE FEVTENTRNL AAQLSAASGP GPEQQLDSVI NLGNETAGAD SRGTLHDGVS
     EGTCPASADA GDTGGSEVQA CPNQSAPNCC EEQEAAGQDC ALGPDSCQGI DGAAADVEPS
     CE