RFTN2_HUMAN
ID RFTN2_HUMAN Reviewed; 501 AA.
AC Q52LD8; Q14DH4; Q2TA69; Q53QE0; Q53SE1; Q96NM3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Raftlin-2;
DE AltName: Full=Raft-linking protein 2;
GN Name=RFTN2; Synonyms=C2orf11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Upon bacterial lipopolysaccharide stimulation, mediates
CC clathrin-dependent internalization of TLR4 in dendritic cells,
CC resulting in activation of TICAM1-mediated signaling and subsequent
CC IFNB1 production. May regulate B-cell antigen receptor-mediated
CC signaling. {ECO:0000250|UniProtKB:Q8CHX7}.
CC -!- INTERACTION:
CC Q52LD8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12278276, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14699};
CC Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
CC -!- SIMILARITY: Belongs to the raftlin family. {ECO:0000305}.
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DR EMBL; AK055136; BAB70861.1; -; mRNA.
DR EMBL; AC020550; AAX93148.1; -; Genomic_DNA.
DR EMBL; AC114800; AAY24079.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70169.1; -; Genomic_DNA.
DR EMBL; BC093966; AAH93966.1; -; mRNA.
DR EMBL; BC111069; AAI11070.1; -; mRNA.
DR EMBL; BC113361; AAI13362.1; -; mRNA.
DR CCDS; CCDS2323.1; -.
DR RefSeq; NP_653230.2; NM_144629.2.
DR AlphaFoldDB; Q52LD8; -.
DR BioGRID; 126225; 13.
DR IntAct; Q52LD8; 8.
DR STRING; 9606.ENSP00000295049; -.
DR iPTMnet; Q52LD8; -.
DR PhosphoSitePlus; Q52LD8; -.
DR BioMuta; RFTN2; -.
DR DMDM; 134047878; -.
DR jPOST; Q52LD8; -.
DR MassIVE; Q52LD8; -.
DR MaxQB; Q52LD8; -.
DR PaxDb; Q52LD8; -.
DR PeptideAtlas; Q52LD8; -.
DR PRIDE; Q52LD8; -.
DR ProteomicsDB; 62422; -.
DR Antibodypedia; 34069; 131 antibodies from 25 providers.
DR DNASU; 130132; -.
DR Ensembl; ENST00000295049.9; ENSP00000295049.3; ENSG00000162944.11.
DR GeneID; 130132; -.
DR KEGG; hsa:130132; -.
DR MANE-Select; ENST00000295049.9; ENSP00000295049.3; NM_144629.3; NP_653230.2.
DR UCSC; uc002uuo.5; human.
DR CTD; 130132; -.
DR DisGeNET; 130132; -.
DR GeneCards; RFTN2; -.
DR HGNC; HGNC:26402; RFTN2.
DR HPA; ENSG00000162944; Tissue enriched (brain).
DR MIM; 618215; gene.
DR neXtProt; NX_Q52LD8; -.
DR OpenTargets; ENSG00000162944; -.
DR PharmGKB; PA162401231; -.
DR VEuPathDB; HostDB:ENSG00000162944; -.
DR eggNOG; ENOG502QVRY; Eukaryota.
DR GeneTree; ENSGT00530000063609; -.
DR HOGENOM; CLU_025878_0_0_1; -.
DR InParanoid; Q52LD8; -.
DR OMA; EENTYSP; -.
DR OrthoDB; 434232at2759; -.
DR PhylomeDB; Q52LD8; -.
DR TreeFam; TF333285; -.
DR PathwayCommons; Q52LD8; -.
DR SignaLink; Q52LD8; -.
DR BioGRID-ORCS; 130132; 9 hits in 1064 CRISPR screens.
DR ChiTaRS; RFTN2; human.
DR GenomeRNAi; 130132; -.
DR Pharos; Q52LD8; Tdark.
DR PRO; PR:Q52LD8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q52LD8; protein.
DR Bgee; ENSG00000162944; Expressed in ventricular zone and 130 other tissues.
DR ExpressionAtlas; Q52LD8; baseline and differential.
DR Genevisible; Q52LD8; HS.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033227; P:dsRNA transport; IEA:Ensembl.
DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR InterPro; IPR028169; Raftlin.
DR PANTHER; PTHR17601; PTHR17601; 1.
DR Pfam; PF15250; Raftlin; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Myristate; Palmitate; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..501
FT /note="Raftlin-2"
FT /id="PRO_0000089338"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT MOD_RES 409
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8CHX7"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT LIPID 3
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 416
FT /note="R -> H (in Ref. 1; BAB70861)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 55922 MW; 8DABA620EDE03E75 CRC64;
MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN PEVIKINSIL
DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV VLLRLKLSPK NSAAPSGQRR
PRLVIEECPL TSEAQTNDAA KELIEKINVA AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI
ESMLHVRHGS DENCRSWNEG TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA
SDNKLYTVFN AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE GCEIKTDYGP
LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP VMWNSAAQTP DKKASRHIKG
EDKNKATSRS IGLDTTSSQP AESRHLPEEC RLSPSRECWT KEGRLAQHNS FSGFSSSDNV
LRELDDGQFD QEDGVTQVTC M
