RFUC_TREPA
ID RFUC_TREPA Reviewed; 377 AA.
AC O83323;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Probable riboflavin import permease protein RfuC {ECO:0000305};
GN Name=rfuC {ECO:0000303|PubMed:23404400};
GN OrderedLocusNames=TP_0301 {ECO:0000312|EMBL:AAC65289.1};
GN ORFNames=TPANIC_0301 {ECO:0000312|EMBL:AGN75505.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=24058545; DOI=10.1371/journal.pone.0074319;
RA Petrosova H., Pospisilova P., Strouhal M., Cejkova D., Zobanikova M.,
RA Mikalova L., Sodergren E., Weinstock G.M., Smajs D.;
RT "Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14:
RT correction of sequencing errors resulted in increased separation of
RT syphilis treponeme subclusters.";
RL PLoS ONE 8:E74319-E74319(2013).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=23404400; DOI=10.1128/mbio.00615-12;
RA Deka R.K., Brautigam C.A., Biddy B.A., Liu W.Z., Norgard M.V.;
RT "Evidence for an ABC-type riboflavin transporter system in pathogenic
RT spirochetes.";
RL MBio 4:E00615-E00615(2013).
CC -!- FUNCTION: Probably part of the ABC transporter complex RfuABCD involved
CC in riboflavin import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000305|PubMed:23404400}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding
CC protein (RfuA). {ECO:0000305|PubMed:23404400}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000305|PubMed:23404400}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AE000520; AAC65289.1; -; Genomic_DNA.
DR EMBL; CP004010; AGN75505.1; -; Genomic_DNA.
DR PIR; G71341; G71341.
DR RefSeq; WP_010881750.1; NC_021490.2.
DR AlphaFoldDB; O83323; -.
DR IntAct; O83323; 2.
DR STRING; 243276.TPANIC_0301; -.
DR TCDB; 3.A.1.2.28; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAC65289; AAC65289; TP_0301.
DR EnsemblBacteria; AGN75505; AGN75505; TPANIC_0301.
DR GeneID; 57878837; -.
DR KEGG; tpa:TP_0301; -.
DR KEGG; tpw:TPANIC_0301; -.
DR PATRIC; fig|243276.9.peg.301; -.
DR eggNOG; COG4603; Bacteria.
DR HOGENOM; CLU_040769_0_3_12; -.
DR OMA; VYFGAFF; -.
DR OrthoDB; 974216at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..377
FT /note="Probable riboflavin import permease protein RfuC"
FT /id="PRO_0000443720"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 40888 MW; DDEE6D472F25AFA8 CRC64;
MKRVINSCIA VLLGVAVMSA VIVLCSENPS VSLAAFFLKP FSTRGYIRAL FHKAGLFVCM
ALGASCALKT GMINLGGDGQ IYAAGFVTAL LLREYWGVGF LLQWSVALLC ALSVAGILAC
VSGILKAWLA TSEMITSFLL STACVPLIDA LIITVTRDPA GNLLATAPVH SHFILQQQTS
LFGVPAVLTY ASLVALAVGC FFSYTRVGYQ FRICGKAPEF GRFVGFPVWA TYVWGMVLSG
ALFGLTGFFS VVGLFGTCYV GFSVGMGYAA LAHALIAHAH ITVLVPLAFF FAWMETASEA
AVLGAHLTVN VVLFLQAAIF LLISAQWSAP WNAVRRGARR VYRFLVTVFC FRGEKHRTRR
RHALSVHDTH HRRSRWE
