RFUD_TREPA
ID RFUD_TREPA Reviewed; 313 AA.
AC O83324;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Probable riboflavin import permease protein RfuD {ECO:0000305};
GN Name=rfuD {ECO:0000303|PubMed:23404400};
GN OrderedLocusNames=TP_0302 {ECO:0000312|EMBL:AAC65290.1};
GN ORFNames=TPANIC_0302 {ECO:0000312|EMBL:AGN75506.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=24058545; DOI=10.1371/journal.pone.0074319;
RA Petrosova H., Pospisilova P., Strouhal M., Cejkova D., Zobanikova M.,
RA Mikalova L., Sodergren E., Weinstock G.M., Smajs D.;
RT "Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14:
RT correction of sequencing errors resulted in increased separation of
RT syphilis treponeme subclusters.";
RL PLoS ONE 8:E74319-E74319(2013).
RN [3]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=23404400; DOI=10.1128/mbio.00615-12;
RA Deka R.K., Brautigam C.A., Biddy B.A., Liu W.Z., Norgard M.V.;
RT "Evidence for an ABC-type riboflavin transporter system in pathogenic
RT spirochetes.";
RL MBio 4:E00615-E00615(2013).
CC -!- FUNCTION: Probably part of the ABC transporter complex RfuABCD involved
CC in riboflavin import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000305|PubMed:23404400}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding
CC protein (RfuA). {ECO:0000305|PubMed:23404400}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000305|PubMed:23404400}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AE000520; AAC65290.1; -; Genomic_DNA.
DR EMBL; CP004010; AGN75506.1; -; Genomic_DNA.
DR PIR; H71341; H71341.
DR RefSeq; WP_010881751.1; NC_021490.2.
DR AlphaFoldDB; O83324; -.
DR IntAct; O83324; 2.
DR STRING; 243276.TPANIC_0302; -.
DR TCDB; 3.A.1.2.28; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAC65290; AAC65290; TP_0302.
DR EnsemblBacteria; AGN75506; AGN75506; TPANIC_0302.
DR GeneID; 57878838; -.
DR KEGG; tpa:TP_0302; -.
DR KEGG; tpw:TPANIC_0302; -.
DR PATRIC; fig|243276.9.peg.302; -.
DR eggNOG; COG1079; Bacteria.
DR HOGENOM; CLU_040769_1_3_12; -.
DR OMA; IARIWVE; -.
DR OrthoDB; 1215743at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..313
FT /note="Probable riboflavin import permease protein RfuD"
FT /id="PRO_5007697175"
FT TRANSMEM 4..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 313 AA; 33534 MW; F50477AC18D3F46E CRC64;
MGVIGTTVIA ILHRAAPLAC AAAGALATEY AGVLGIFMEG VITFSSFCIA FFALVWGSYW
GGLGITVCVV PLCLFFVAVG TERMRANPFL TGIAVHFSAM GMSAFGASSM FARAAASAMQ
MDTAAHGVSF THVSLAHTRV LPHPLWGTAV AFALVWVFHL YLYSTNVGIN FMHSGEGALA
LQVRGTDAAR YRMVSWAVAG VCAVCAGGLL VLRVGTYTPQ MAAGRGWTAL AIVFLARKRM
MWCVPAAIFF SGIEHMCDVL QGTHVVPTGV LFALPYILSL VVFVCTRRTS PCRRGERRRS
RLLFAYLQRV TCA
