RFX1_CANAL
ID RFX1_CANAL Reviewed; 851 AA.
AC Q59V88; A0A1D8PT55;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transcriptional regulator RFX1;
GN Name=RFX1; OrderedLocusNames=CAALFM_CR06110CA;
GN ORFNames=CaO19.11346, CaO19.3865;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Transcription factor involved in DNA damage responses,
CC morphogenesis, and virulence. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
CC -!- INDUCTION: Induced during biofilm formation.
CC {ECO:0000269|PubMed:22265407}.
CC -!- SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE-
CC ProRule:PRU00858}.
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DR EMBL; CP017630; AOW31322.1; -; Genomic_DNA.
DR RefSeq; XP_713492.2; XM_708399.2.
DR AlphaFoldDB; Q59V88; -.
DR SMR; Q59V88; -.
DR STRING; 237561.Q59V88; -.
DR PRIDE; Q59V88; -.
DR GeneID; 3644844; -.
DR KEGG; cal:CAALFM_CR06110CA; -.
DR CGD; CAL0000174984; RFX1.
DR VEuPathDB; FungiDB:CR_06110C_A; -.
DR eggNOG; KOG3712; Eukaryota.
DR HOGENOM; CLU_011526_1_0_1; -.
DR InParanoid; Q59V88; -.
DR OrthoDB; 346630at2759; -.
DR PRO; PR:Q59V88; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619; PTHR12619; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation; Virulence.
FT CHAIN 1..851
FT /note="Transcriptional regulator RFX1"
FT /id="PRO_0000426089"
FT DNA_BIND 282..357
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00858"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 96111 MW; 86E7B9A38489F462 CRC64;
MSSDQTPQNR NRGGDDSYNP RLQQQTSQIP STGPDQGQQR ERSQEQESDH EHQQAQQHLH
QFQQSNLTPS TTAFPSSTSI PTFSKQDQGY HNQFSSPQSS YRKIGNFAQS SNAPFLNEPH
PIYATNYQQN VPSQSQFQFD YSSPYIGQSQ SQSQSQSQAQ PQPHPQPQTY QQLPHYSQAS
VSSLPPTYQA FHSMHEASSA DNDSATNITT PQKRKKQKRS ESVTPNTGEN ELKQLALRSS
NIPLSELAQK VKQLENDSTT TSVSLEQSKM KENKETQRQL FGMVWLLNSC DLAPTAVIPR
NRIYARYVQV CADNNLAPVS PASFGKLVKI LYPNITTRRL GMRGQSKYHY CGIKLTGDEN
MQSQLLNYQQ KQKHQSQEQY NQQAQVGSST SSAGLAGHQS PMSSCNSSVS YEESPGPIIS
RAHTPSFSPI NTPTISMSKS LNDQLPSISH MKFIPNLFYL LNSNVATSSN PHEPIQLPSI
YPYLSKDADH DIADTLYSLY KVHVNSIFEA LRYMQLKKLF SSFSTFNNIL TAPVLKLYTT
ESLAEWVMKC DLIMYKKMIR MLSKLQLQLL IPQEQLLQLK QIADGYIKTL STSLINSKVS
QNFVMMKLKL AKHFVNLLNR LIKVIETGQP ASRILNDDNE KNTMTQDWMK LDIHGIICRE
MPCNDNNIDT LTYILTGEVV NLIKVKSDNE QAPTMSDFAN YISNLPSRFP EVNTRLFLLL
ASNLLTTCLR EISLSGGEGF GAWWIVRCWI DEYLAWSFEV GGFFQDDLQE IVAQQQLNVQ
LPPPSLSSLP QTQQQNPVIQ EETGTQEESL GNIDLLETSF DFDAKTSQPY QQPSHTESLL
NFETNIDNLL N
