ID   RFX3_DANRE              Reviewed;         765 AA.
AC   A0JMF8;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transcription factor RFX3;
DE   AltName: Full=Regulatory factor X 3;
GN   Name=rfx3; ORFNames=zgc:153245;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for ciliogenesis and islet cell
CC       differentiation during endocrine pancreas development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
CC   -!- SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00858}.
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DR   EMBL; BC125862; AAI25863.1; -; mRNA.
DR   RefSeq; NP_001073517.1; NM_001080048.1.
DR   AlphaFoldDB; A0JMF8; -.
DR   SMR; A0JMF8; -.
DR   STRING; 7955.ENSDARP00000041235; -.
DR   PaxDb; A0JMF8; -.
DR   PeptideAtlas; A0JMF8; -.
DR   PRIDE; A0JMF8; -.
DR   GeneID; 570989; -.
DR   KEGG; dre:570989; -.
DR   CTD; 5991; -.
DR   ZFIN; ZDB-GENE-061103-253; rfx3.
DR   eggNOG; KOG3712; Eukaryota.
DR   InParanoid; A0JMF8; -.
DR   OrthoDB; 346630at2759; -.
DR   PhylomeDB; A0JMF8; -.
DR   PRO; PR:A0JMF8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619; PTHR12619; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..765
FT                   /note="Transcription factor RFX3"
FT                   /id="PRO_0000392995"
FT   DNA_BIND        189..264
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00858"
SQ   SEQUENCE   765 AA;  84548 MW;  8F2D57190FA0BE3A CRC64;
     MQTPEAGADS TVSTVPLQTS VPVQPAVSGQ QVASQVPVQQ QAQTVQQVQH VYQAQVQYVQ
     EENNSVYTNG TIRAYSYSEP QLYNQNSSGN YFDTQGGGGS AAQVSTVVST HSMANNGNGT
     GALAMGLTGG QIISSSGAYL IGGNSMDGSA PHGAAQTTRA SPATIEMAIE TLQKSEGLSS
     QRSSLLNSHL QWLLDNYETA EGVSLPRSTL YNHYLRHCQE QKLDPVNAAS FGKLIRSIFM
     GLRTRRLGTR GNSKYHYYGI RVKPDSPLNR LQEDMQYMAL RQQPVQQKQR FKPVQKMDGV
     SGDNFSSAGQ HTPSAAEQTF IAQSQHHQQF LDGSRALPEF VELDLGEAVD GVGPEDVKAL
     QTLYREHCEA ILDVVVNLQF NLIENLWQTF WRYSASSSVE GVTITENSGL SEIEGRLPRA
     RLILLCRHEA VHKWMNTCDH LMYQALVEIL IPDVLRPIPS ALTQAIRNFA KSLEGWLTNA
     MSSIPPRMIN TKVSAVSAFA QTLRRYTSLN HLAQAARAVL QNTSQINQML SDLNRVDFAN
     VQEQASWVCQ CEEGVVQRLE QDFKATLQQQ SSLEQWAAWL DNVVTQILKP YEDKPTLPKA
     ARQFLLKWSF YSSMVIRDLT LRSAASFGSF HLIRLLYDEY MFYLVEHRVA QATGETAIGV
     MGEFQDLNTM SPANIDKDEV SEMDSDLDEE MEEADEPLAK REKVEADVIQ VLQVGAMEDG
     SSAVVGIVQP SMINSLPPTT NNHSEHILST GTSTIRHVGN TYASV