ID   RFX3_MACFA              Reviewed;         749 AA.
AC   Q4R3I8;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Transcription factor RFX3;
DE   AltName: Full=Regulatory factor X 3;
GN   Name=RFX3; ORFNames=QtsA-16695;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for ciliogenesis and islet cell
CC       differentiation during endocrine pancreas development. Essential for
CC       the differentiation of nodal monocilia and left-right asymmetry
CC       specification during embryogenesis. Required for the biogenesis of
CC       motile cilia by governing growth and beating efficiency of motile
CC       cells. Also required for ciliated ependymal cell differentiation.
CC       Regulates the expression of genes involved in ciliary assembly
CC       (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility
CC       (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6,
CC       participates in the differentiation of 4 of the 5 islet cell types
CC       during endocrine pancreas development, with the exception of pancreatic
CC       PP (polypeptide-producing) cells. Regulates transcription by forming a
CC       heterodimer with another RFX protein and binding to the X-box in the
CC       promoter of target genes. Represses transcription of MAP1A in non-
CC       neuronal cells but not in neuronal cells (By similarity).
CC       {ECO:0000250|UniProtKB:P48380, ECO:0000250|UniProtKB:P48381}.
CC   -!- SUBUNIT: Heterodimer; heterodimerizes with RFX1 and RFX2, and RFX6.
CC       {ECO:0000250|UniProtKB:P48380}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
CC   -!- SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00858}.
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DR   EMBL; AB179278; BAE02329.1; -; mRNA.
DR   AlphaFoldDB; Q4R3I8; -.
DR   SMR; Q4R3I8; -.
DR   STRING; 9541.XP_005581871.1; -.
DR   PRIDE; Q4R3I8; -.
DR   eggNOG; KOG3712; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619; PTHR12619; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..749
FT                   /note="Transcription factor RFX3"
FT                   /id="PRO_0000392994"
FT   DNA_BIND        183..258
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00858"
FT   REGION          663..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  83558 MW;  32B566627FF012B5 CRC64;
     MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV
     EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS AQVTTVVSSH SMVGTGGIQM
     GVTGGQLISS SGGTYLIGNS MENSGHSVTH TTRASPATIE MAIETLQKSD GLSTHRSSLL
     NSHLQWLLDN YETAEGVSLP RSTLYDHYLR HCQEHKLDPV NAASFGKLIR SIFMGLRTRR
     LGTRGNSKYH YYGIRVKPDS PLNRLQEDMQ YMAMRQQPMQ QKQRYKPMQK VDGVADGFTG
     SGQQTGTSVE QTVIAQSQHH QQFLDASRAL PEFGEVEISS LPDGTTFEDI KSLQSLYREH
     CEAILDVVVN LQFSLIEKLW QTFWRYSPST PTDGTTITES SNLSEIESRL PKAKLITLCK
     HESILKWMCN CDHGMYQALV EILIPDVLRP IPSALTQAIR NFAKSLEGWL SNAMNNIPQR
     MIQTKVAAVS AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLNDLNRVD FANVQEQASW
     VCQCDDNMVQ RLETDFKMTL QQQSTLEQWA AWLDNVMMQA LKPYEGRPSF PKAARQFLLK
     WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAQATGETP IAVMGEFGDL
     NAVSPGNLDK DEGSEVESEM DEELDDSSEP QAKREKTELS QAFPVGCMQP VLETGVQPSL
     LNPIHSEHIV TSTQTIRQCS ATGNTYTAV