ID   RFX3_XENTR              Reviewed;         749 AA.
AC   Q0V9K5;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transcription factor RFX3;
DE   AltName: Full=Regulatory factor X 3;
GN   Name=rfx3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for ciliogenesis and islet cell
CC       differentiation during endocrine pancreas development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
CC   -!- SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00858}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI21501.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC121500; AAI21501.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001263620.1; NM_001276691.1.
DR   RefSeq; XP_017949734.1; XM_018094245.1.
DR   AlphaFoldDB; Q0V9K5; -.
DR   SMR; Q0V9K5; -.
DR   STRING; 8364.ENSXETP00000012258; -.
DR   PaxDb; Q0V9K5; -.
DR   Ensembl; ENSXETT00000012258; ENSXETP00000012258; ENSXETG00000011698.
DR   GeneID; 779608; -.
DR   KEGG; xtr:779608; -.
DR   CTD; 5991; -.
DR   Xenbase; XB-GENE-1021689; rfx3.
DR   eggNOG; KOG3712; Eukaryota.
DR   InParanoid; Q0V9K5; -.
DR   OrthoDB; 346630at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011698; Expressed in 4-cell stage embryo and 7 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0060285; P:cilium-dependent cell motility; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619; PTHR12619; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..749
FT                   /note="Transcription factor RFX3"
FT                   /id="PRO_0000392996"
FT   DNA_BIND        183..258
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00858"
SQ   SEQUENCE   749 AA;  83354 MW;  2A0B02B602FCBC24 CRC64;
     MQTSETVSDT GSTVTLQTSV AGQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV
     EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGGS AQVTTVVSTH SMVGTGGIQM
     GVTGGQIISS TGGTYLIGNA MENSGHSVSH TTRASPATIE MAIETLQKSD GLSSHRSSLL
     NSHLQWLLDN YETAEGVSLP RSTLYNHYLR HCQEHKLDPV NAASFGKLIR SIFMGLRTRR
     LGTRGNSKYH YYGIRVKPDS PLNRLQEDMQ YMAMRQQPMQ QKQRYKPMQK VDGVGDGFAG
     SGQSGASVEQ TVIAQSQHHQ QFLDASRALP EFAEVEISSL PDGTTFEDIK SLQSLYREHC
     EAILDVVVNL QFSLIEKLWQ TFWRYSPSSP ADGSTITESG NLSEIESRLP KSKLILFCKN
     ESIVKWMCNC DHMMYQSLVE ILIPDVLRPI PSALTQAVRN FAKSLEGWLS SAMSNIPQRM
     IQTKVAAVSA FAQTLRRYTS LNHLAQAARA VLQNTSQINQ MLNDLNRVDF ANVQEQASWV
     CQCDDSMVQR LETDFKMTLQ QQSTLEQWAA WLDNVVTQAL KPYEGRPSFP KAARQFLLKW
     SFYSSMVIRD LTLRSAASFG SFHLIRLLYD EYMFYLVEHR VAQATGESPI AVMGEFGDLN
     DASPGNMEKD EGSDVESEIE EELDDSVEPP AKREKTELSQ AFQVGCMQPS LEGSVQQSLV
     LNQLHSEHIV TSTQTIRQCS ATGNTYTAV