ID   RFX8_MOUSE              Reviewed;         596 AA.
AC   D3YU81;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA-binding protein RFX8;
DE   AltName: Full=Regulatory factor X 8;
GN   Name=Rfx8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May be a transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858}.
CC   -!- SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00858}.
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DR   EMBL; AC119809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC122922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS48245.1; -.
DR   RefSeq; NP_001139132.1; NM_001145660.1.
DR   AlphaFoldDB; D3YU81; -.
DR   SMR; D3YU81; -.
DR   IntAct; D3YU81; 1.
DR   STRING; 10090.ENSMUSP00000121212; -.
DR   iPTMnet; D3YU81; -.
DR   PhosphoSitePlus; D3YU81; -.
DR   PaxDb; D3YU81; -.
DR   PRIDE; D3YU81; -.
DR   ProteomicsDB; 255190; -.
DR   Antibodypedia; 55182; 17 antibodies from 9 providers.
DR   Ensembl; ENSMUST00000151913; ENSMUSP00000121212; ENSMUSG00000057173.
DR   GeneID; 619289; -.
DR   KEGG; mmu:619289; -.
DR   UCSC; uc007atn.2; mouse.
DR   CTD; 731220; -.
DR   MGI; MGI:3588206; Rfx8.
DR   VEuPathDB; HostDB:ENSMUSG00000057173; -.
DR   eggNOG; KOG3712; Eukaryota.
DR   GeneTree; ENSGT01050000244879; -.
DR   HOGENOM; CLU_039469_0_0_1; -.
DR   InParanoid; D3YU81; -.
DR   OMA; ITSFWKS; -.
DR   OrthoDB; 346630at2759; -.
DR   PhylomeDB; D3YU81; -.
DR   TreeFam; TF342109; -.
DR   BioGRID-ORCS; 619289; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Rfx8; mouse.
DR   PRO; PR:D3YU81; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; D3YU81; protein.
DR   Bgee; ENSMUSG00000057173; Expressed in spermatid and 16 other tissues.
DR   Genevisible; D3YU81; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619; PTHR12619; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..596
FT                   /note="DNA-binding protein RFX8"
FT                   /id="PRO_0000395345"
FT   DNA_BIND        19..94
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00858"
SQ   SEQUENCE   596 AA;  67285 MW;  7ACA3944E1BEF5B3 CRC64;
     MAEAVPASPA SGLGLHRGII QWLVDNFCIC EGFSVPRCLM YEIYVETCGQ SAQNQVNPAT
     FGKLVRLVFP DLGTRRLGTR GSARYHYDGI YIKKSSFFYA HYCYLLGKKS CHSGNLIAFG
     KFPDYSNVLQ QEETCENHSP IKKDPMGSPV SPFRRCPVWE QELANKYSCK LVVFLADEYC
     NYCRDILQNV RNQELEKVED LITSFWKSRQ QDTVMLMSLP DVRQLLGCYD MQLYKGLEDM
     LLPDFLEDVS IQYLKSVRLF SKRFKLWLLG ALEGFPAILQ ISKLKEVTGF VKRLRRKTYL
     SNMAKTMKMV LKNSRRIGLL KSDLRAIIRE GTLDISKKVL EGDSDHEEEP ESHTEMKCLG
     CLISLLETST DLAELLNCVS SNLQVLVFQP SKNKEDFIKL AASFQLKWNF LLTAVSKAMT
     LSHRDSFGAW HLFHLLLLEY VIHILESCIE EEEEEDLGSL QDLLSDDQFL TQPDQALFHP
     LDSLPTSECA SRNVESPQVT LKHTSQSCGP MGMGSVVLQV LGFLVDTATG NKLVQVLLED
     KTTESAVKLS LPVGQEALIT LSNGQRFVIH ISDVPQSSEN TYCRKSNANV QGGLLE