ID   RG1BB_DANRE             Reviewed;         475 AA.
AC   Q6DBW1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Ras-GEF domain-containing family member 1B-B;
GN   Name=rasgef1bb {ECO:0000312|ZFIN:ZDB-GENE-040801-220};
GN   Synonyms=rasgef {ECO:0000303|PubMed:17239665}; ORFNames=zgc:91814;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH78340.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   DEVELOPMENTAL STAGE.
RX   PubMed=17239665; DOI=10.1016/j.modgep.2006.11.010;
RA   Epting D., Vorwerk S., Hageman A., Meyer D.;
RT   "Expression of rasgef1b in zebrafish.";
RL   Gene Expr. Patterns 7:389-395(2007).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) for Ras family
CC       proteins. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout embryogenesis from the
CC       blastula sphere stage (4 hours post fertilization).
CC       {ECO:0000269|PubMed:17239665}.
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DR   EMBL; BC078340; AAH78340.1; -; mRNA.
DR   RefSeq; NP_001003479.1; NM_001003479.1.
DR   AlphaFoldDB; Q6DBW1; -.
DR   SMR; Q6DBW1; -.
DR   STRING; 7955.ENSDARP00000064967; -.
DR   PaxDb; Q6DBW1; -.
DR   Ensembl; ENSDART00000064968; ENSDARP00000064967; ENSDARG00000044251.
DR   Ensembl; ENSDART00000182968; ENSDARP00000148041; ENSDARG00000117029.
DR   GeneID; 445085; -.
DR   KEGG; dre:445085; -.
DR   CTD; 445085; -.
DR   ZFIN; ZDB-GENE-040801-220; rasgef1bb.
DR   eggNOG; KOG3541; Eukaryota.
DR   GeneTree; ENSGT00940000155816; -.
DR   HOGENOM; CLU_022907_2_0_1; -.
DR   InParanoid; Q6DBW1; -.
DR   OMA; KKAITQM; -.
DR   OrthoDB; 533115at2759; -.
DR   PhylomeDB; Q6DBW1; -.
DR   TreeFam; TF313379; -.
DR   PRO; PR:Q6DBW1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000044251; Expressed in heart and 24 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Ras-GEF domain-containing family member 1B-B"
FT                   /id="PRO_0000341486"
FT   DOMAIN          36..166
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT   DOMAIN          209..456
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          452..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..475
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  55441 MW;  079290539F0DE7FD CRC64;
     MPQTTPYSSK FNPSAYSSSH SHRQPVEENY GGLHYRDNKL VSGSLEALIQ LLVPTVDYYP
     DRSYIFTFLL SSRLFLNPFE LMSRVCYLGV DHHRVGDPQM DKKRIRDIAP KIVQLLTEWT
     ETFPYDFRDE RMMRSLKEMT HRLAFGDELS RRAMQRLIQR LLRKLTTLGQ YEESLATTSA
     AAAIDRPVAL KSKQQLVRRD DCVLNLCDDP FIFAQQLTHI EMERLSYIGP EEFVRAFAQK
     RPSDNHKSFF SKRKASNLEA YVEWFNRLSY LTATEICMPV KKKHRARVLE FFIDVAQECF
     NIGNFNSLMA IITGMNMNPV SRLKKTWGKV NTDKFDILVH QMDPSSNFYS YRTALRGATQ
     RSSTAHTSQE MIVIPFFSLF IKDIYFLNEG CANRLSNGHI NFEKFWELAK QVSEFLSWRQ
     VICPFERDRK TLQYLISAPV FSEDELQLAS YESEGPENNL ERDTRRSLRS SLSRM