RGA1_SOLBU
ID RGA1_SOLBU Reviewed; 979 AA.
AC Q7XA42; Q7XA21;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Putative disease resistance protein RGA1;
DE AltName: Full=RGA3-blb;
GN Name=RGA1; Synonyms=177O13.37, CB3A14.4;
OS Solanum bulbocastanum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=147425;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RX PubMed=12872003; DOI=10.1073/pnas.1533501100;
RA Song J., Bradeen J.M., Naess S.K., Raasch J.A., Wielgus S.M.,
RA Haberlach G.T., Liu J., Kuang H., Austin-Phillips S., Buell C.R.,
RA Helgeson J.P., Jiang J.;
RT "Gene RB cloned from Solanum bulbocastanum confers broad spectrum
RT resistance to potato late blight.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:9128-9133(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14675451; DOI=10.1046/j.1365-313x.2003.01934.x;
RA van der Vossen E., Sikkema A., Hekkert Bt B.L., Gros J., Stevens P.,
RA Muskens M., Wouters D., Pereira A., Stiekema W., Allefs S.;
RT "An ancient R gene from the wild potato species Solanum bulbocastanum
RT confers broad-spectrum resistance to Phytophthora infestans in cultivated
RT potato and tomato.";
RL Plant J. 36:867-882(2003).
CC -!- FUNCTION: Disease resistance protein. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via a direct or indirect interaction with this avirulence protein. That
CC triggers a defense system which restricts the pathogen growth.
CC -!- INDUCTION: Constitutively expressed.
CC -!- MISCELLANEOUS: Belongs to a four-gene family located at the same locus.
CC Although the four genes are expressed in the resistant haplotype, only
CC RGA2 confers the resistance to P.infestans. In the susceptible
CC haplotype, RGA1 and RGA3 are likely to be pseudogenes created by
CC deletions and mutations, while RGA2 contains also several
CC modifications.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP45185.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY303170; AAP45163.2; -; Genomic_DNA.
DR EMBL; AY303171; AAP45185.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AY426261; AAR29071.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7XA42; -.
DR SMR; Q7XA42; -.
DR PRIDE; Q7XA42; -.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Repeat.
FT CHAIN 1..979
FT /note="Putative disease resistance protein RGA1"
FT /id="PRO_0000212777"
FT DOMAIN 143..437
FT /note="NB-ARC"
FT REPEAT 524..547
FT /note="LRR 1"
FT REPEAT 549..570
FT /note="LRR 2"
FT REPEAT 571..594
FT /note="LRR 3"
FT REPEAT 595..619
FT /note="LRR 4"
FT REPEAT 637..661
FT /note="LRR 5"
FT REPEAT 748..773
FT /note="LRR 6"
FT REPEAT 823..841
FT /note="LRR 7"
FT REPEAT 842..866
FT /note="LRR 8"
FT REPEAT 868..890
FT /note="LRR 9"
FT REPEAT 891..915
FT /note="LRR 10"
FT REPEAT 917..939
FT /note="LRR 11"
FT REPEAT 940..965
FT /note="LRR 12"
FT BINDING 182..189
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VARIANT 88
FT /note="Q -> L (in susceptible haplotype)"
FT VARIANT 149
FT /note="P -> S (in susceptible haplotype)"
FT VARIANT 166
FT /note="I -> T (in susceptible haplotype)"
FT VARIANT 559
FT /note="F -> V (in susceptible haplotype)"
FT VARIANT 563
FT /note="N -> S (in susceptible haplotype)"
FT VARIANT 566
FT /note="K -> R (in susceptible haplotype)"
FT VARIANT 593..635
FT /note="SKLGSLRNLLLDGCSLTSTPPRIGLLTCLKSLSCFVIGKRKGH -> ISKLL
FT CYWQEKGY (in susceptible haplotype)"
FT VARIANT 715
FT /note="R -> L (in susceptible haplotype)"
FT VARIANT 762
FT /note="D -> E (in susceptible haplotype)"
FT VARIANT 770..795
FT /note="Missing (in susceptible haplotype)"
FT VARIANT 970
FT /note="A -> S (in susceptible haplotype)"
FT CONFLICT 125
FT /note="K -> N (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 168..169
FT /note="TA -> NV (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="I -> V (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="N -> D (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="M -> V (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 570
FT /note="K -> R (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 635
FT /note="H -> Y (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 661
FT /note="T -> S (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 795
FT /note="M -> K (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 830
FT /note="V -> A (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 852
FT /note="D -> N (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 874
FT /note="K -> N (in Ref. 1; AAP45185 and 2; AAR29071)"
FT /evidence="ECO:0000305"
FT CONFLICT 903
FT /note="D -> N (in Ref. 2; AAR29071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 979 AA; 111271 MW; 66189FA22B9FE38D CRC64;
MAEAFIQVVL DNLTSFLKGE LVLLFGFQDE FQRLSSMFST IQAVLEDAQE KQLNDKPLEN
WLQKLNAATY EVDDILDEYK TKATRFLQSE YGRYHPKVIP FRHKVGKRMD QVMKKLNAIA
EERKKFHLQE KIIERQAATR ETGSVLTEPQ VYGRDKEKDE IVKILINTAS DAQKLSVLPI
LGMGGLGKTT LSQMVFNDQR VTERFYPKIW ICISDDFNEK RLIKAIVESI EGKSLSDMDL
APLQKKLQEL LNGKRYFLVL DDVWNEDQHK WANLRAVLKV GASGAFVLTT TRLEKVGSIM
GTLQPYELSN LSPEDCWFLF MQRAFGHQEE INPNLMAIGK EIVKKCGGVP LAAKTLGGIL
RFKREEREWE HVRDSPIWNL PQDESSILPA LRLSYHHLPL DLRQCFVYCA VFPKDTKMAK
ENLIAFWMAH GFLLSKGNLE LEDVGNEVWN ELYLRSFFQE IEVESGKTYF KMHDLIHDLA
TSLFSANTSS SNIREINANY DGYMMSIGFA EVVSSYSPSL LQKFVSLRVL NLRNSNLNQL
PSSIGDLVHL RYLDLSGNFR IRNLPKRLCK LQNLQTLDLH YCDSLSCLPK QTSKLGSLRN
LLLDGCSLTS TPPRIGLLTC LKSLSCFVIG KRKGHQLGEL KNLNLYGSIS ITKLDRVKKD
TDAKEANLSA KANLHSLCLS WDLDGKHRYD SEVLEALKPH SNLKYLEING FGGIRLPDWM
NQSVLKNVVS IRIRGCENCS CLPPFGELPC LESLELHTGS ADVEYVEDNV HPGRFPSLRK
LVIWDFSNLK GLLKMEGEKQ FPVLEEMTFY WCPMFVIPTL SSVKTLKVIV TDATVLRSIS
NLRALTSLDI SDNVEATSLP EEMFKSLANL KYLKISFFRN LKELPTSLAS LNALKSLKFE
FCDALESLPE EGVKGLTSLT ELSVSNCMML KCLPEGLQHL TALTTLTITQ CPIVFKRCER
GIGEDWHKIA HIPYLTLYE
