RGA3_SOLBU
ID RGA3_SOLBU Reviewed; 992 AA.
AC Q7XA40; Q7XA25;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Putative disease resistance protein RGA3;
DE AltName: Full=Blight resistance protein B149;
DE AltName: Full=RGA1-blb;
GN Name=RGA3; Synonyms=177O13.36, CB3A14.6;
OS Solanum bulbocastanum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=147425;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RX PubMed=12872003; DOI=10.1073/pnas.1533501100;
RA Song J., Bradeen J.M., Naess S.K., Raasch J.A., Wielgus S.M.,
RA Haberlach G.T., Liu J., Kuang H., Austin-Phillips S., Buell C.R.,
RA Helgeson J.P., Jiang J.;
RT "Gene RB cloned from Solanum bulbocastanum confers broad spectrum
RT resistance to potato late blight.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:9128-9133(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14675451; DOI=10.1046/j.1365-313x.2003.01934.x;
RA van der Vossen E., Sikkema A., Hekkert Bt B.L., Gros J., Stevens P.,
RA Muskens M., Wouters D., Pereira A., Stiekema W., Allefs S.;
RT "An ancient R gene from the wild potato species Solanum bulbocastanum
RT confers broad-spectrum resistance to Phytophthora infestans in cultivated
RT potato and tomato.";
RL Plant J. 36:867-882(2003).
CC -!- FUNCTION: Disease resistance protein. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via a direct or indirect interaction with this avirulence protein. That
CC triggers a defense system which restricts the pathogen growth.
CC -!- INDUCTION: Constitutively expressed.
CC -!- MISCELLANEOUS: Belongs to a four-gene family located at the same locus.
CC Although the four genes are expressed in the resistant haplotype, only
CC RGA2 confers the resistance to P.infestans. In the susceptible
CC haplotype, RGA1 and RGA3 are likely to be pseudogenes created by
CC deletions and mutations, while RGA2 contains also several
CC modifications.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AY303170; AAP45165.2; -; Genomic_DNA.
DR EMBL; AY303171; AAP45181.2; -; Genomic_DNA.
DR EMBL; AY426260; AAR29070.1; -; Genomic_DNA.
DR EMBL; AY426263; AAR29073.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7XA40; -.
DR SMR; Q7XA40; -.
DR PRIDE; Q7XA40; -.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Repeat.
FT CHAIN 1..992
FT /note="Putative disease resistance protein RGA3"
FT /id="PRO_0000212779"
FT DOMAIN 135..437
FT /note="NB-ARC"
FT REPEAT 534..556
FT /note="LRR 1"
FT REPEAT 557..580
FT /note="LRR 2"
FT REPEAT 582..603
FT /note="LRR 3"
FT REPEAT 604..628
FT /note="LRR 4"
FT REPEAT 646..672
FT /note="LRR 5"
FT REPEAT 680..703
FT /note="LRR 6"
FT REPEAT 758..783
FT /note="LRR 7"
FT REPEAT 787..811
FT /note="LRR 8"
FT REPEAT 813..837
FT /note="LRR 9"
FT REPEAT 855..879
FT /note="LRR 10"
FT REPEAT 881..903
FT /note="LRR 11"
FT REPEAT 904..928
FT /note="LRR 12"
FT BINDING 182..189
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VARIANT 154
FT /note="R -> K (in susceptible haplotype)"
FT VARIANT 173
FT /note="E -> K (in susceptible haplotype)"
FT VARIANT 533..571
FT /note="Missing (in susceptible haplotype)"
FT VARIANT 775
FT /note="Y -> F (in susceptible haplotype)"
FT VARIANT 782
FT /note="L -> P (in susceptible haplotype)"
FT VARIANT 808..810
FT /note="KGA -> EGE (in susceptible haplotype)"
FT VARIANT 847
FT /note="G -> R (in susceptible haplotype)"
FT VARIANT 879
FT /note="N -> S (in susceptible haplotype)"
FT VARIANT 884
FT /note="I -> K (in susceptible haplotype)"
FT VARIANT 890
FT /note="F -> Y (in susceptible haplotype)"
FT CONFLICT 6
FT /note="L -> I (in Ref. 2; AAR29073)"
FT /evidence="ECO:0000305"
FT CONFLICT 460
FT /note="E -> G (in Ref. 2; AAR29073)"
FT /evidence="ECO:0000305"
FT CONFLICT 581
FT /note="Q -> R (in Ref. 2; AAR29073)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 992 AA; 113283 MW; A0A92D7FC22AE6C8 CRC64;
MAEAFLQVLL DNLTFFIQGE LGLVFGFEKE FKKLSSMFSM IQAVLEDAQE KQLKYKAIKN
WLQKLNVAAY EVDDILDDCK TEAARFKQAV LGRYHPRTIT FCYKVGKRMK EMMEKLDAIA
EERRNFHLDE RIIERQAARR QTGFVLTEPK VYGREKEEDE IVKILINNVS YSEEVPVLPI
LGMGGLGKTT LAQMVFNDQR ITEHFNLKIW VCVSDDFDEK RLIKAIVESI EGKSLGDMDL
APLQKKLQEL LNGKRYFLVL DDVWNEDQEK WDNLRAVLKI GASGASILIT TRLEKIGSIM
GTLQLYQLSN LSQEDCWLLF KQRAFCHQTE TSPKLMEIGK EIVKKCGGVP LAAKTLGGLL
RFKREESEWE HVRDSEIWNL PQDENSVLPA LRLSYHHLPL DLRQCFAYCA VFPKDTKIEK
EYLIALWMAH SFLLSKGNME LEDVGNEVWN ELYLRSFFQE IEVKSGKTYF KMHDLIHDLA
TSMFSASASS RSIRQINVKD DEDMMFIVTN YKDMMSIGFS EVVSSYSPSL FKRFVSLRVL
NLSNSEFEQL PSSVGDLVHL RYLDLSGNKI CSLPKRLCKL QNLQTLDLYN CQSLSCLPKQ
TSKLCSLRNL VLDHCPLTSM PPRIGLLTCL KTLGYFVVGE RKGYQLGELR NLNLRGAISI
THLERVKNDM EAKEANLSAK ANLHSLSMSW DRPNRYESEE VKVLEALKPH PNLKYLEIID
FCGFCLPDWM NHSVLKNVVS ILISGCENCS CLPPFGELPC LESLELQDGS VEVEYVEDSG
FLTRRRFPSL RKLHIGGFCN LKGLQRMKGA EQFPVLEEMK ISDCPMFVFP TLSSVKKLEI
WGEADAGGLS SISNLSTLTS LKIFSNHTVT SLLEEMFKNL ENLIYLSVSF LENLKELPTS
LASLNNLKCL DIRYCYALES LPEEGLEGLS SLTELFVEHC NMLKCLPEGL QHLTTLTSLK
IRGCPQLIKR CEKGIGEDWH KISHIPNVNI YI
