RGA4S_ORYSJ
ID RGA4S_ORYSJ Reviewed; 1014 AA.
AC F7J0M6; A0A0P0Y0F1; Q2R8L3;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Disease resistance protein RGA4 {ECO:0000305};
DE AltName: Full=Os11gRGA4 {ECO:0000312|EMBL:BAK39924.1};
GN Name=RGA4 {ECO:0000303|PubMed:21251109};
GN OrderedLocusNames=Os11g0225100 {ECO:0000312|EMBL:BAT13283.1},
GN LOC_Os11g11790 {ECO:0000312|EMBL:ABA92206.2};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Hitomebore {ECO:0000312|EMBL:BAK39924.1},
RC cv. Mokoto {ECO:0000312|EMBL:BAK39924.1}, and
RC cv. Nipponbare {ECO:0000312|EMBL:BAK39924.1};
RC TISSUE=Leaf {ECO:0000312|EMBL:BAK39924.1};
RX PubMed=21251109; DOI=10.1111/j.1365-313x.2011.04502.x;
RA Okuyama Y., Kanzaki H., Abe A., Yoshida K., Tamiru M., Saitoh H.,
RA Fujibe T., Matsumura H., Shenton M., Galam D.C., Undan J., Ito A., Sone T.,
RA Terauchi R.;
RT "A multifaceted genomics approach allows the isolation of the rice Pia-
RT blast resistance gene consisting of two adjacent NBS-LRR protein genes.";
RL Plant J. 66:467-479(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Probable disease resistance protein. Resistance proteins
CC guard the plant against pathogens that contain an appropriate
CC avirulence protein via an indirect interaction with this avirulence
CC protein. That triggers a defense system including the hypersensitive
CC response, which restricts the pathogen growth. At the opposite of
CC cultivars Aichi asahi and Sasanishiki, the cultivars Nipponbare, Mokoto
CC and Hitomebore don't recognize the effector avirulence protein AVR-Pia
CC from M.oryzae. {ECO:0000269|PubMed:21251109}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves. {ECO:0000269|PubMed:21251109}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABA92206.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAG90195.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAH95163.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAT13283.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB604624; BAK39924.1; -; mRNA.
DR EMBL; DP000010; ABA92206.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008217; BAH95163.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014967; BAT13283.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK066950; BAG90195.1; ALT_INIT; mRNA.
DR RefSeq; XP_015617249.1; XM_015761763.1.
DR RefSeq; XP_015617250.1; XM_015761764.1.
DR RefSeq; XP_015617251.1; XM_015761765.1.
DR RefSeq; XP_015617252.1; XM_015761766.1.
DR AlphaFoldDB; F7J0M6; -.
DR SMR; F7J0M6; -.
DR PRIDE; F7J0M6; -.
DR EnsemblPlants; Os11t0225100-01; Os11t0225100-01; Os11g0225100.
DR GeneID; 9271293; -.
DR Gramene; Os11t0225100-01; Os11t0225100-01; Os11g0225100.
DR KEGG; osa:9271293; -.
DR OrthoDB; 161833at2759; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1014
FT /note="Disease resistance protein RGA4"
FT /id="PRO_0000444660"
FT DOMAIN 189..466
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 484..506
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 507..530
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 531..552
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 580..602
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 603..624
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 625..647
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 701..725
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 762..784
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 785..807
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 808..833
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 854..877
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REGION 1..182
FT /note="Structured coiled coil (CC) domain"
FT /evidence="ECO:0000250|UniProtKB:F7J0M4"
FT COILED 105..145
FT /evidence="ECO:0000255"
SQ SEQUENCE 1014 AA; 113314 MW; C4A83A1AE4AA35F9 CRC64;
MEAALLSGFI KAILPRLFSL VNDKLNLHKG VKGDIDFLIK ELRMIVGAID DDLSVEHGAA
AAAAAVQTLC MEDLRELAHG IEDCIDGVLY RAAREQRRSS SLLPRTVRAT KKLLQTNQHL
AQELQRLKRM VEEANQRKQR YTAAAPGQHG QVYSSAAAQV DEPWPSCSSA SDPRIHEADL
VGVDADRAEL LEQLAERQPE QLKVIAIVGF CGLGKTALAA EAYNRETRGG RFERHAWVCA
AHRSAREVLG ELLRRIDAAC HGDSDAGQLC VDIRQQLEKK RYFIVIDDIQ TEDQWKSIKS
AFPTDKDIGS RIVVTTTIQS VANACCSANG YLHKMSRLDK NCSKQLLSKK ACPERYSHYK
QPDSAAILKK CDGQPLALVT IGEFLQANGW PTGPNCEDLC NRLHYHLEND KTLERMRRVL
VRNYTSLPGH ALKACLLYFG MFPSDHPIRR KSLLRRWLAE GFVEPVSSSS NLDSTAAFDV
LMDRNIIEPI NVSNNDKVKT CQTYGMMREF ISHMSISQNF VTFFCDDKFL PKYVRRLSLH
GDTVVNGDNF NGIDLSLVRS LVVFGEAGTT VLDFSKYQLL RVLDLEKCDD LNDDHLKEIC
NLVLLKYLSL GGNISKLPKD IAKLKDLEAL DVRRSKVKIM PVEVFGLPCL IHLLGKFKLS
DKVKQKTEVQ EFLSKGKSNL QTLAGFASNG SEGFLHLMRY MNKLRKLKIW CTSSAGSTDW
TDLREAIQQF ILDEKEANIG TRSLSLHFTG CSEDAINSLK EPCYLSSLKL HGNFPQLPQF
VTSLRGLKEL CLSSTKFTTG LLEALSNLSY LQYLKLVADE LEKFIIKVQG FPRLLCLCIV
LQCPTFPVIE EGALPFLVTL QLLCKDLHGL SDIKIECFKH LQEVTLHSGV TPATRQEWVK
AAKEHPNRPK VLLLKSVDTA ESEHTDVDSV MEAVKSETTE YSIAPEGPEQ VIDMNNKMQL
DHGLESSSVL NKQNNFADQS SSKDQLHYSF NNMGLSDVSP AVSELPNGMV PSCT
