RGA4_SOLBU
ID RGA4_SOLBU Reviewed; 988 AA.
AC Q7XA39; Q7XA32;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Putative disease resistance protein RGA4;
DE AltName: Full=RGA4-blb;
GN Name=RGA4; Synonyms=177O13.34, CB3A14.8;
OS Solanum bulbocastanum (Wild potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=147425;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RX PubMed=12872003; DOI=10.1073/pnas.1533501100;
RA Song J., Bradeen J.M., Naess S.K., Raasch J.A., Wielgus S.M.,
RA Haberlach G.T., Liu J., Kuang H., Austin-Phillips S., Buell C.R.,
RA Helgeson J.P., Jiang J.;
RT "Gene RB cloned from Solanum bulbocastanum confers broad spectrum
RT resistance to potato late blight.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:9128-9133(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14675451; DOI=10.1046/j.1365-313x.2003.01934.x;
RA van der Vossen E., Sikkema A., Hekkert Bt B.L., Gros J., Stevens P.,
RA Muskens M., Wouters D., Pereira A., Stiekema W., Allefs S.;
RT "An ancient R gene from the wild potato species Solanum bulbocastanum
RT confers broad-spectrum resistance to Phytophthora infestans in cultivated
RT potato and tomato.";
RL Plant J. 36:867-882(2003).
CC -!- FUNCTION: Disease resistance protein. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via a direct or indirect interaction with this avirulence protein. That
CC triggers a defense system which restricts the pathogen growth.
CC -!- INDUCTION: Constitutively expressed.
CC -!- MISCELLANEOUS: Belongs to a four-gene family located at the same locus.
CC Although the four genes are expressed in the resistant haplotype, only
CC RGA2 confers the resistance to P.infestans. In the susceptible
CC haplotype, RGA1 and RGA3 are likely to be pseudogenes created by
CC deletions and mutations, while RGA2 contains also several
CC modifications.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AY303170; AAP45166.1; -; Genomic_DNA.
DR EMBL; AY303171; AAP45174.1; -; Genomic_DNA.
DR EMBL; AY426262; AAR29072.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7XA39; -.
DR SMR; Q7XA39; -.
DR PRIDE; Q7XA39; -.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 2.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW ATP-binding; Leucine-rich repeat; Nucleotide-binding; Plant defense;
KW Repeat.
FT CHAIN 1..988
FT /note="Putative disease resistance protein RGA4"
FT /id="PRO_0000212780"
FT DOMAIN 137..439
FT /note="NB-ARC"
FT REPEAT 526..548
FT /note="LRR 1"
FT REPEAT 549..572
FT /note="LRR 2"
FT REPEAT 574..595
FT /note="LRR 3"
FT REPEAT 596..620
FT /note="LRR 4"
FT REPEAT 638..662
FT /note="LRR 5"
FT REPEAT 674..696
FT /note="LRR 6"
FT REPEAT 751..776
FT /note="LRR 7"
FT REPEAT 784..808
FT /note="LRR 8"
FT REPEAT 829..851
FT /note="LRR 9"
FT REPEAT 852..876
FT /note="LRR 10"
FT REPEAT 878..900
FT /note="LRR 11"
FT REPEAT 901..925
FT /note="LRR 12"
FT REPEAT 927..950
FT /note="LRR 13"
FT REPEAT 966..988
FT /note="LRR 14"
FT BINDING 184..191
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VARIANT 45
FT /note="L -> V (in susceptible haplotype)"
FT VARIANT 120
FT /note="S -> A (in susceptible haplotype)"
FT VARIANT 305
FT /note="L -> S (in susceptible haplotype)"
FT VARIANT 512
FT /note="A -> S (in susceptible haplotype)"
FT VARIANT 692
FT /note="K -> E (in susceptible haplotype)"
FT CONFLICT 145
FT /note="G -> VGWQWGWARLEYKRLLLGVLMRIMSLRMHVSTCSTLYEFKFYLCTPK
FT VGARRC (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 988 AA; 111996 MW; D04DFF348BCFDAD3 CRC64;
MAEAFLQVLL ENLTSFIGDK LVLIFGFEKE CEKLSSVFST IQAVLQDAQE KQLKDKAIEN
WLQKLNSAAY EVDDILGECK NEAIRFEQSR LGFYHPGIIN FRHKIGRRMK EIMEKLDAIS
EERRKFHFLE KITERQAAAA TRETGFVLTE PKVYGRDKEE DEIVKILINN VNVAEELPVF
PIIGMGGLGK TTLAQMIFND ERVTKHFNPK IWVCVSDDFD EKRLIKTIIG NIERSSPHVE
DLASFQKKLQ ELLNGKRYLL VLDDVWNDDL EKWAKLRAVL TVGARGASIL ATTRLEKVGS
IMGTLQPYHL SNLSPHDSLL LFMQRAFGQQ KEANPNLVAI GKEIVKKCGG VPLAAKTLGG
LLRFKREESE WEHVRDNEIW SLPQDESSIL PALRLSYHHL PLDLRQCFAY CAVFPKDTKM
IKENLITLWM AHGFLLSKGN LELEDVGNEV WNELYLRSFF QEIEAKSGNT YFKIHDLIHD
LATSLFSASA SCGNIREINV KDYKHTVSIG FAAVVSSYSP SLLKKFVSLR VLNLSYSKLE
QLPSSIGDLL HLRYLDLSCN NFRSLPERLC KLQNLQTLDV HNCYSLNCLP KQTSKLSSLR
HLVVDGCPLT STPPRIGLLT CLKTLGFFIV GSKKGYQLGE LKNLNLCGSI SITHLERVKN
DTDAEANLSA KANLQSLSMS WDNDGPNRYE SKEVKVLEAL KPHPNLKYLE IIAFGGFRFP
SWINHSVLEK VISVRIKSCK NCLCLPPFGE LPCLENLELQ NGSAEVEYVE EDDVHSRFST
RRSFPSLKKL RIWFFRSLKG LMKEEGEEKF PMLEEMAILY CPLFVFPTLS SVKKLEVHGN
TNTRGLSSIS NLSTLTSLRI GANYRATSLP EEMFTSLTNL EFLSFFDFKN LKDLPTSLTS
LNALKRLQIE SCDSLESFPE QGLEGLTSLT QLFVKYCKML KCLPEGLQHL TALTNLGVSG
CPEVEKRCDK EIGEDWHKIA HIPNLDIH
