RGA5S_ORYSJ
ID RGA5S_ORYSJ Reviewed; 1301 AA.
AC Q2R8L1;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Disease resistance protein RGA5 {ECO:0000305};
DE AltName: Full=Os11gRGA5 {ECO:0000312|EMBL:BAK39932.1};
GN Name=RGA5 {ECO:0000312|EMBL:BAK39932.1};
GN OrderedLocusNames=Os11g0225300 {ECO:0000312|EMBL:BAT13285.1},
GN LOC_Os11g11810 {ECO:0000312|EMBL:ABA92208.1};
GN ORFNames=OsJ_33425 {ECO:0000312|EMBL:EEE51878.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Hitomebore {ECO:0000312|EMBL:BAK39932.1},
RC cv. Mokoto {ECO:0000312|EMBL:BAK39932.1}, and
RC cv. Nipponbare {ECO:0000312|EMBL:BAK39932.1};
RC TISSUE=Leaf {ECO:0000312|EMBL:BAK39932.1};
RX PubMed=21251109; DOI=10.1111/j.1365-313x.2011.04502.x;
RA Okuyama Y., Kanzaki H., Abe A., Yoshida K., Tamiru M., Saitoh H.,
RA Fujibe T., Matsumura H., Shenton M., Galam D.C., Undan J., Ito A., Sone T.,
RA Terauchi R.;
RT "A multifaceted genomics approach allows the isolation of the rice Pia-
RT blast resistance gene consisting of two adjacent NBS-LRR protein genes.";
RL Plant J. 66:467-479(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Probable disease resistance protein. Resistance proteins
CC guard the plant against pathogens that contain an appropriate
CC avirulence protein via an indirect interaction with this avirulence
CC protein. That triggers a defense system including the hypersensitive
CC response, which restricts the pathogen growth. At the opposite of
CC cultivars Aichi asahi and Sasanishiki, the cultivars Nipponbare, Mokoto
CC and Hitomebore don't recognize the effector avirulence protein AVR-Pia
CC from M.oryzae. {ECO:0000269|PubMed:21251109}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves. {ECO:0000269|PubMed:21251109}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
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DR EMBL; AB604629; BAK39932.1; -; mRNA.
DR EMBL; DP000010; ABA92208.1; -; Genomic_DNA.
DR EMBL; AP008217; BAF27900.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT13285.1; -; Genomic_DNA.
DR EMBL; CM000148; EEE51878.1; -; Genomic_DNA.
DR EMBL; AK072355; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q2R8L1; -.
DR STRING; 4530.OS11T0225300-01; -.
DR PaxDb; Q2R8L1; -.
DR PRIDE; Q2R8L1; -.
DR EnsemblPlants; Os11t0225300-01; Os11t0225300-01; Os11g0225300.
DR Gramene; Os11t0225300-01; Os11t0225300-01; Os11g0225300.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_1_1; -.
DR InParanoid; Q2R8L1; -.
DR OMA; ETATWDI; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000007752; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR ExpressionAtlas; Q2R8L1; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; PTHR23155; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW Plant defense; Reference proteome; Repeat.
FT CHAIN 1..1301
FT /note="Disease resistance protein RGA5"
FT /id="PRO_0000444662"
FT DOMAIN 181..464
FT /note="NB-ARC"
FT /evidence="ECO:0000255"
FT REPEAT 604..627
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 629..649
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 650..671
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 673..697
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 728..751
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 790..813
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 861..885
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 1020..1043
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 1060..1083
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 1117..1140
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 1141..1163
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 1164..1186
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REGION 1..177
FT /note="Structured coiled coil (CC) domain"
FT /evidence="ECO:0000250|UniProtKB:F7J0N2"
FT REGION 1214..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 711
FT /note="N -> Y (in Ref. 7; AK072355)"
FT /evidence="ECO:0000305"
FT CONFLICT 843
FT /note="K -> E (in Ref. 7; AK072355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1301 AA; 147040 MW; BC26FD09412ADB96 CRC64;
MDAPVSFSLG AMGPLLRKLD SLPVAPEIRL PEPLKDGIEL LKEDLEEIGA ALVEQSMVDS
PSHRARYWMD EVRDLSYHIE DCIDTMFSMR CGGDDGKPRS VRRHKVGRVK VDGFSKTQKP
CTRLARIAEL RALVREASER HERYQLGDGR ASSSSSSSHR VFTAHGQVPA PCRNLVGMDE
PKTKLTNMLT DEAELHMKVV CILGSAGIGK TTLAEQVYRK LRWQFDCHAF VRASRKPDMR
RLLGAILSQV QLRIRISDTS TVQSLIDNLW EYLQKKRYFI VIDELYETAT WDIITSAFPE
DNNCSRIMTT AGIEGVALEC CSYHSVNIFK MIPLGLDDSA KLFFNRVFGS EQQCPYELNE
VSYRITAKCG GLPLAVIIIA GLLASLPCKT ELWYNIDGCL CSSVTTDIDL DEILKEIISL
GYDNLPHYLK TCLLYLSLYS EGFIIWTADL LKQWISEGFI AVIDGEDIEE VAESYFYNLV
NRGMIQSVKT KYNNQVLCTV HHTVFDLIIH KSKEEKFISA IDYSQTMPGN SLEARRLSFH
FSNTRYATEV AGITLSQVRS FAFLGLLKCM PSIMEFKLLR VLILEFWGDN HGCMSFNVAR
ICRLFQLRYL KISSQIIIEL PAQIRGLKYL ETLEIDARVT AIPSDIIHLR SLLHLYFQDG
IVLPDGIGCI RSLRTLKYFD LGSNSEENIR SLGQLTNLRD LHLTCSAPKS NQQAKRNLVI
LASYTGKLGN LKSVKFSPGD SGMDISFLFY GIGISVDRSR TASSLPFSVR TLELPSICIF
ARLPDWIGQL RKLHTLNLAV RELIENDIDS LAGLPDLIVL SMHIMKAPME RIVFNRKAFP
VLKYFKFICG TLRMAFQAGA MANLHRLKLG FNAHKGEKYD NILVGIEHLL NLKKIAVRIG
GAAEAKESDR MAAEAALKEA IRKHLMFLDD LDIARVECVK EEYKCIKKKH KIKIEDSISE
KNGDSKKQHS VEKKAVWGKT MKNIADSGVF PEDYTMSREQ RVAEGFVVGI EKCRAEDAAE
RIIRNVPVDY DGLGQVSTSK IQDHLPELAP RAVQNEKFGS SNDLSIMIQI NKYARLPSYE
WRDTDISKLN FRLLRAPMLL EAVTARCHLL DLILIGSNNI TVLDLGRPTI TKLPASIECL
PNLRYLRLQG TQLKSLSEVI VKMPTIRGLD IKNTKTEELP QGILRMKKLS HLSMGEKQKN
IQVFMEKMQT LAETVQDSDD LSDETEGIAD DEGEFSTRAN ASTPKVDEDE VDRRANNFIA
RFRKQITIRN SGFAKKESSI DERLWIRDLD ECQLSKRGGR F
