RGA7_SCHPO
ID RGA7_SCHPO Reviewed; 695 AA.
AC O94466;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable Rho-GTPase-activating protein 7;
GN Name=rga7; ORFNames=SPBC23G7.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-497, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
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DR EMBL; CU329671; CAA22624.1; -; Genomic_DNA.
DR PIR; T39954; T39954.
DR RefSeq; NP_595866.1; NM_001021771.2.
DR AlphaFoldDB; O94466; -.
DR SMR; O94466; -.
DR BioGRID; 277161; 27.
DR STRING; 4896.SPBC23G7.08c.1; -.
DR iPTMnet; O94466; -.
DR MaxQB; O94466; -.
DR PaxDb; O94466; -.
DR PRIDE; O94466; -.
DR EnsemblFungi; SPBC23G7.08c.1; SPBC23G7.08c.1:pep; SPBC23G7.08c.
DR GeneID; 2540635; -.
DR KEGG; spo:SPBC23G7.08c; -.
DR PomBase; SPBC23G7.08c; rga7.
DR VEuPathDB; FungiDB:SPBC23G7.08c; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_010730_3_0_1; -.
DR InParanoid; O94466; -.
DR OMA; IADSGWQ; -.
DR PhylomeDB; O94466; -.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR Reactome; R-SPO-9013148; CDC42 GTPase cycle.
DR Reactome; R-SPO-9013405; RHOD GTPase cycle.
DR Reactome; R-SPO-9013424; RHOV GTPase cycle.
DR Reactome; R-SPO-9035034; RHOF GTPase cycle.
DR PRO; PR:O94466; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR GO; GO:0098753; C:anchored component of the cytoplasmic side of the plasma membrane; IDA:PomBase.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0032154; C:cleavage furrow; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:PomBase.
DR GO; GO:0110085; C:mitotic actomyosin contractile ring; IDA:PomBase.
DR GO; GO:0120104; C:mitotic actomyosin contractile ring, proximal layer; IDA:PomBase.
DR GO; GO:0005096; F:GTPase activator activity; IMP:PomBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:PomBase.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IMP:PomBase.
DR GO; GO:0140278; P:mitotic division septum assembly; IMP:PomBase.
DR GO; GO:1903138; P:negative regulation of cell wall integrity MAPK cascade; IMP:PomBase.
DR GO; GO:0140281; P:positive regulation of mitotic division septum assembly; IMP:PomBase.
DR GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; GTPase activation; Phosphoprotein; Reference proteome.
FT CHAIN 1..695
FT /note="Probable Rho-GTPase-activating protein 7"
FT /id="PRO_0000097315"
FT DOMAIN 33..307
FT /note="F-BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01077"
FT DOMAIN 506..692
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 496
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 497
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 695 AA; 76679 MW; 1DEAF1328D576263 CRC64;
MLSAPSSSTT PASPPTSPPN TTSSDDFAVL KEPKVEAILN SELGLAILND RIKDYLLTCK
ELAGFFKKRS ILEEESGKNL QKLAKSYLET FQSKHHSPQS FSASVITSME IHEQLANHSL
TLQKTLSAFS DQVIEFHKNA ERKRKSIKEY AKKQENAYLE AVMQMDKSKS RFKGAETEYN
RALDNKNTGD SQKKVGFFKP KSNAQLTKLE DEARLKAENA ESDMHSKIEN AQNVQKQLLC
IHRPNYIKQF FSLQREIESS LIANYLRYTK LCESNTLLNG LTIRPQKPTP TNCGLQHALD
NINANTDFVQ YVLHASIKHE DNKNPTDASK TKIIQPPSSY GTGSSAGKTN PPVNPTIKVT
AAIPSPLQNT NPAPSTFPNP SVASPAFPNS STSNPSTAPA SASPLASTLK PSTANDTNGS
SSSSSSNPRT SSPLASNAEN KPPVAQQSPP VLLPTLPPIQ TTTIQTSREV APPPSSINSN
RAASPFRPTS VSPQPSSPTK SLLFGARLDA IILREHSNIP NIVMQCTSQV ENFGLNLQGI
YRVPSSSARV NMLRSQFENN PLLQLHTPED YENDVHAVAD LLKIFFRELR EPLIPDNHQR
DFIDAGNVED ESRRRDAVHR AINDLPDANY STIRHLTIHL AKIKENSDVN KMSTNNLAII
WGPTIIKQAT IPEISSFSRT IEILIDYCFT IFDYD
