ID   RGAP6_ARATH             Reviewed;         827 AA.
AC   Q9FMP8; Q0WM40;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Rho GTPase-activating protein 6;
DE   AltName: Full=Rho-type GTPase-activating protein 6;
GN   Name=ROPGAP6; OrderedLocusNames=At5g12150; ORFNames=MXC9.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA   Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT   features of the regions of 1,191,918 bp covered by seventeen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:401-414(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 466-827.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a GTPase activator for the Rac-type GTPase by
CC       converting it to an inactive GDP-bound state. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9FMP8-1; Sequence=Displayed;
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DR   EMBL; AB007727; BAB10033.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91768.1; -; Genomic_DNA.
DR   EMBL; AK229992; BAF01816.1; -; mRNA.
DR   EMBL; AY065176; AAL38352.1; -; mRNA.
DR   RefSeq; NP_196776.1; NM_121253.5. [Q9FMP8-1]
DR   AlphaFoldDB; Q9FMP8; -.
DR   SMR; Q9FMP8; -.
DR   STRING; 3702.AT5G12150.1; -.
DR   iPTMnet; Q9FMP8; -.
DR   PaxDb; Q9FMP8; -.
DR   PRIDE; Q9FMP8; -.
DR   ProteomicsDB; 236963; -. [Q9FMP8-1]
DR   EnsemblPlants; AT5G12150.1; AT5G12150.1; AT5G12150. [Q9FMP8-1]
DR   GeneID; 831088; -.
DR   Gramene; AT5G12150.1; AT5G12150.1; AT5G12150. [Q9FMP8-1]
DR   KEGG; ath:AT5G12150; -.
DR   Araport; AT5G12150; -.
DR   TAIR; locus:2176992; AT5G12150.
DR   eggNOG; KOG4271; Eukaryota.
DR   HOGENOM; CLU_011283_1_0_1; -.
DR   InParanoid; Q9FMP8; -.
DR   OMA; DQNVVQQ; -.
DR   PhylomeDB; Q9FMP8; -.
DR   PRO; PR:Q9FMP8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FMP8; baseline and differential.
DR   Genevisible; Q9FMP8; AT.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:TAIR.
DR   GO; GO:0009920; P:cell plate formation involved in plant-type cell wall biogenesis; IGI:TAIR.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR025757; MIP1_Leuzipper.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF14389; Lzipper-MIP1; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; GTPase activation; Reference proteome.
FT   CHAIN           1..827
FT                   /note="Rho GTPase-activating protein 6"
FT                   /id="PRO_0000422721"
FT   DOMAIN          18..125
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          172..371
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          379..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          560..684
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        391..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  91352 MW;  CF34DD0F19887689 CRC64;
     MEASLAVIQR PQAGASNTVY KSGPLFISSK GLGWTSWKKR WFILTRTSLV FFKNDPSALP
     QKGGEVNLTL GGIDLNSSGS VVVREDKKLL TVLFPDGRDG RAFTLKAETL DDLYEWKAAL
     EQALAQAPNA ALVIGQNGIF RTEANNTIEA SFNSWRDQRP LKSSVVGRPI LLALEEIDGS
     PSFLEKALQF LETYGTKVEG ILRQSADVEE VERRVQEYEQ GKTEFSPEED PHVVGDCVKH
     VLRQLPSSPV PASCCTALLE AYKIDQNEAR VNSLRSAIIE TFPEPNRRLL LRMLKMMHTI
     TSHSSENRMT SSAVAACMSP LLLRPLLAGE CDLEGFDTLG DNSAQLLAAA NAANNAQAIV
     TALLEDYGNM INDEGLGRCS TSTDSHIGDS GPENSSDEEE IVVKHPDLHT LDIEEGETDD
     DNDVLLSRKP SESSDYAGSD LYDYKGFGVE DSDAESPRDI HCSVESTDFS ARVKKHIEEP
     IKDIEVSSVS PTENCYQSGR EAIPSVTPST PLTALRYTTS AEKPASKTTG SSTVNSKRSS
     SWGRGNGKKT PAKGSFDSSG NDELLIQRLE HMKDELRQRI AKEAKGNAAL QASLERRKQA
     LHERRLALEQ DVGRLQEQLQ AERDLRSALE VGLSISCGQF SSQAADSKTR AELEEIALAE
     ADVARLKQKV AELHHQLSQQ RQHHLSSLPD AQSHHQFLHN HNTQLKSFQQ DFDSILAFVN
     HERNQRTDET SLRADWRNGR GNNRQVPGSP SLNAASLGIP MEEYSPVMDY GRHHHPPATS
     AALMELTTRL DFFKERRSQL MEQIQNLDLN YGSSSSSLHR SSSPPWN